https://hdl.handle.net/10259/3726 2026-05-27T04:34:17Z https://hdl.handle.net/10259/11733 Effectiveness of Stem Cell Secretomes in the Regeneration and Functional Recovery of Severed Nerves in Patients with Nerve Injuries: A Systematic Review Nevado Sánchez, Endika; Rodríguez Díaz, María; Núñez Rodríguez, Sandra; Bueno de la Fuente, Andrea Victoria; Fuente Anuncibay, Raquel de la; Villar Suárez, Vega; González Bernal, Jerónimo; Labrador Gómez, Jorge The regenerative potential of mesenchymal stem cell (MSC) secretomes in peripheral nerve injuries warrants rigorous evaluation. This systematic review analyzes their effectiveness in preclinical models of neurotmesis, a complete transection of a nerve. Neurophysiological recovery was assessed through nerve conduction velocity (NCV), a measure of the speed at which electrical impulses travel along a nerve. Following PRISMA guidelines, a systematic search was conducted in PubMed, Scopus, Web of Science, and ScienceDirect (last search July 2024). From 640 initially identified studies, 13 met inclusion criteria, encompassing 514 animals (rats). experimental designs published since 2014 in English or Spanish, focusing on MSC secretomes for nerve regeneration. Exclusion criteria included reviews, case reports, and incomplete data. The risk of bias was assessed using Joanna Briggs Institute tools. Results were synthesized narratively, focusing on functional and structural outcomes. The included studies employed various MSC sources, including adipose tissue, olfactory mucosa, and umbilical cord. Nine studies reported enhanced SFI, favoring secretome-treated groups over controls (mean difference +20.5%, p < 0.01). Seven studies documented increased NCV, with up to 35% higher conduction velocities in treated groups (p < 0.05). Histological outcomes reported in 12 studies showed increased axonal diameter (+25%, p < 0.01), myelin sheath thickness (+30%, p < 0.05), and Schwann cell proliferation. Limitations of the included evidence include methodological heterogeneity and variability in outcome measurement tools. MSC-derived secretomes demonstrate potential as advanced therapeutic strategies for nerve injuries. Personalized approaches considering injury type and clinical context are essential for optimizing outcomes. 2025-03-01T00:00:00Z https://hdl.handle.net/10259/11731 Desarrollo de funciones ejecutivas y creatividad en educación infantil Garcia Pascual, Maria Rocio; Cuesta Gómez, José Luis; Fuente Anuncibay, Raquel de la; Uribe Gil, Lina María Resumen Introducción: el desarrollo de las funciones ejecutivas en la autorregulación de la conducta y desarrollo de procesos cognitivos de orden superior pone en evidencia su importancia en el éxito escolar y social. Algunos estudios sugieren que puede existir relación con la creatividad, siendo de gran relevancia determinar los procesos de desarrollo de ambos conceptos y ver su relación. Objetivo: estudiar la relación entre funciones ejecutivas y creatividad en una muestra de alumnos de edades comprendidas entre los 3 y los 5 años y 11 meses. Materiales y método: para medir la función ejecutiva se utilizó el BRIEF-P (Gioia et al., 2016) y para la medir la creatividad el cuestionario de creatividad de Tuttle (1980). La correlación se midió mediante estadística paramétrica. Resultados: los resultados mostraron que existe relación estadísticamente significativa entre la creatividad y el Índice General de Función Ejecutiva (IGE), existe correlación significativa con el Índice de Metacognición Emergente (IME) sin embargo, no se encontró relación entre los índices de Autocontrol Inhibitorio (IAI) y de Flexibilidad (IFL). Los alumnos de menor edad presentan mayores dificultades en las escalas de inhibición, flexibilidad y control emocional. Conclusiones: la existencia de relación entre la función ejecutiva y la creatividad abre la puerta a más investigaciones en este campo, siendo necesario ampliar la muestra. Se señala la importancia de diseñar e implementar programas educativos en la etapa de Educación Infantil para potenciarlas.; Introduction: The development of executive functions in the self-regulation of behavior and the development of higher-order cognitive processes highlight their importance in academic success. Some studies suggest that there may be a relationship with creativity, making it highly relevant to determine the developmental processes of both concepts and to explore their relationship. Objective: To study the relationship between executive functions and creativity in a sample of students aged between 3 years and 5 years and 11 months. Materials and Method: The BRIEF-P (Gioia et al., 2016) was used to measure executive function, and Tuttle’s creativity questionnaire (1980) was used to measure creativity. The correlation was measured using parametric statistics. Results: The results showed a statistically significant relationship between creativity and the Global Executive Function Index (GEFI), with a significant correlation with the Emerging Metacognition Index (EMI). However, no relationship was found between the Inhibitory Self-Control Index (ISCI) and the Flexibility Index (FI). Younger students showed more difficulties in the scales of inhibition, flexibility, and emotional control. Conclusions: The existence of a relationship between executive function and creativity opens the door to further research in this field, with an expansion of the sample size being necessary. It highlights the importance of designing and implementing educational programs in Early Childhood Education to enhance these skills. 2025-01-01T00:00:00Z https://hdl.handle.net/10259/11719 Upper limb replantation: functional disability and quality of life challenges Bueno de la Fuente, Andrea Victoria; Núñez Rodríguez, Sandra; Fuente Anuncibay, Raquel de la; Estefanía Díez, Miguel Eugenio; Nevado Sánchez, Endika; González Bernal, Jerónimo Background: Upper limb replantation, while surgically complex, demands a multidimensional assessment of functional recovery, subjective satisfaction, and quality of life beyond mere anatomical survival of the limb. Objective: This study aimed to evaluate the functional outcomes, health-related quality of life, and perceived satisfaction of patients after upper limb replantation, with special attention to the impact of surgical reintervention, rehabilitation, and return to work. Methods: We conducted a cross-sectional observational study including 62 patients treated at a referral center between 2021 and 2023. Patients were assessed using validated instruments (DASH, SF-12, Russell test) alongside clinical and sociodemographic data. Statistical analyses explored associations between reintervention, functionality, quality of life, and work reintegration. Results: Nearly half of the patients required reintervention, which was significantly associated with greater functional disability in occupational and recreational contexts and lower subjective use of the hand in daily activities. Return to work was linked to better functional scores, although quality of life measures showed limited association with functional outcomes. Conclusion: Surgical reintervention and failure to return to work are key factors associated with perceived disability after upper limb replantation. These findings highlight the need for individualized, multidisciplinary follow-up protocols that integrate functional, psychological, and occupational rehabilitation strategies to optimize patient recovery. 2026-04-01T00:00:00Z https://hdl.handle.net/10259/9251 Follow-up study of children and adolescents during the stay-at-home directive decreed during the COVID-19 pandemic: how the way lockdown is interpreted affects mental health Ordóñez Camblor, Nuria; Ubillos Landa, Silvia; González Castro, José Luis; Pizarro Ruiz, Juan Pablo The present study is, to the best of our knowledge, the first study to follow up on the mental health of children and adolescents in Spain during COVID-19, a country in which a strict stay-at-home directive was issued as a result of the pandemic. We also explore the influence of fear of contagion and the attribution for lockdown on young people’s mental health. A sample of 278 children (8 to 12 years) and adolescents (13 to 18 years) were assessed at two time points in relation to different areas linked to well-being, fear of contagion and interpretation of the stringent lockdown as (i) a Punishment, (ii) a means of Slowing the Spread of the Virus, or (iii) a way of Protecting Others. The first time point (T1) was from March 22–25, 2020 (eight to eleven days into lockdown), and the second (T2) was from April 11–14, 2020 (28 to 31 days into lockdown). The results indicate that, following the initial impact of the lockdown, the deterioration observed in the mental health of children and adolescents seemed to stabilize, despite the prolonged nature of the strict stay-at-home directive. A more negative interpretation of the lockdown and greater fear of contagion by the COVID-19 virus resulted in poorer mental health. The present study may help inform the decision-making process regarding stringent lockdown orders for children and adolescents in future pandemics and establish guidelines for providing better support both during and after health crises. 2023-06-26T00:00:00Z