https://hdl.handle.net/10259/12236 Thu, 29 Oct 2026 11:05:54 GMT 2026-10-29T11:05:54Z https://hdl.handle.net/10259/12294 Development of a methodology to perform toxicokinetics and toxicodynamics studies in biofilms Rumbo Lorenzo, Carlos; Collado, Sara; González Plaza, Juan José; Fuente Vivas, Dalia de la; Fernández Pampín, Natalia; Baccaro, Marta; Van den Brink, Nico W.; Barros García, Rocío; Martel Martín, Sonia; Tamayo Ramos, Juan Antonio Environmental research has focussed on elucidating and modelling of toxicokinetics and toxicodynamics of different types of nanomaterials in soil and aquatic organisms, and also in biofilms. The first steps towards the developing of a protocol to analyse Multi Component NanoMaterials (MCNMs) and High Aspect Ratio Nanoparticles (HARNs) tokicokinetics and toxicodynamics in biofilms are described here, using P. putida as model organism. Póster presentado en: 21º Congreso Internacional de la European Society of Toxicology In Vitro (ESTIV 2022), 21 al 25 de noviembre de 2022 en Barcelona-Sitges, España Sat, 01 Jan 2022 00:00:00 GMT https://hdl.handle.net/10259/12294 2022-01-01T00:00:00Z https://hdl.handle.net/10259/12293 Desarrollo de una metodología para evaluar el impacto toxicológico de nuevos nanomateriales sobre biofilms bacterianos Fuente Vivas, Dalia de la; Collado, Sara; Fernández Pampín, Natalia; Dasgupta, Nandita; Gómez Cuadrado, Laura; Barros García, Rocío; Martel Martín, Sonia; Rumbo Lorenzo, Carlos Durante los últimos años, el incremento del uso de nanopartículas (NP) en diversos ámbitos, como medicina o agricultura, despierta la necesidad de evaluar el riesgo que suponen para la salud y el medio ambiente. En este sentido, los biofilms se consideran excelentes candidatos para ser utilizados en estudios de eco-toxicidad, por su capacidad para acumular y responder rápidamente a xenobióticos. Sin embargo, no existe un protocolo estandarizado, habiendo únicamente un artículo publicado al respecto (Chaumet et al., 2019). Este trabajo aborda el desarrollo de una metodología para la ejecución de estudios de toxicocinética y toxicodinámica en biofilms formados por Pseudomonas putida tratados con nanopartículas (NP) de ZnO:Mn. Póster presentado en: XXIX Congreso de la Sociedad Española de Microbiología (SEM 2023), Universidad de Burgos, 25 al 28 de junio de 2023 Sun, 01 Jan 2023 00:00:00 GMT https://hdl.handle.net/10259/12293 2023-01-01T00:00:00Z https://hdl.handle.net/10259/12253 The Role of Dynamic 3D Models in Evaluating MXenes Toxicity: A Focus on Pulmonary and Hepatic Cells Fuente Vivas, Dalia de la; Parra de la Parra, Sandra de la; Sendra Vega, Marta; Rumbo Lorenzo, Carlos; Martel Martín, Sonia; Barros García, Rocío; Gómez Cuadrado, Laura Background: MXenes and Graphene possess outstanding physicochemical properties. They have strong application potential in electronics, energy storage, and biomedicine. Challenge: Current nanoparticle regulations present critical gaps, particularly in human health risk assessment. There is a growing need for Safe and Sustainable by Design (SSbD) aligned evaluation strategies. Aim: To bridge the in vitro–in vivo gap in nanosafety research. Approach: Advanced in vitro models, including static and dynamic 3D cellular systems, were applied and compared to conventional 2D cultures. Impact: These methodologies offer promising tools for improving the hazard assessment of 2D-nanomaterials, such as MXenes. Póster presentado en: 59th Congress of the European Societies of Toxicology (EUROTOX 2025) "Toxicology addresses society's real life risks for sustainable health and well being", 14-17 September 2025, Athens, Greece Wed, 01 Jan 2025 00:00:00 GMT https://hdl.handle.net/10259/12253 2025-01-01T00:00:00Z https://hdl.handle.net/10259/12250 PEST-PD:The Pathto Early Parkinson´s Detection Preliminary Findings from an Ongoing Longitudinal Observational Study for Prodromal Parkinson’s disease in farmers exposed to pesticides Gómez Cuadrado, Laura; García García, David; Canepa Oneto, Antonio Jesús; Lara, Daniel de; Alonso Núñez, Belén; López Marín, Sofía; Fuente Vivas, Dalia de la; Villanueva Alameda, María Isabel; Barros García, Rocío; Aparicio Martínez, Santiago; Rodríguez Diez, Juan José; López Nozal, Carlos; Ramírez Sanz, José Miguel; Gómez-Gregoris, Irene; Catón, Beatriz; Díaz Hurtado, Jorge; Calvo Simal, Sara; Trigo, Javier; Sánchez, Javier; Lisei, Darío; Olalla Gallo, Mª Ángeles; Allende del Río, Marta; Rivadeneyra Posadas, Jéssica Jannett; Begum, Bacinoglu Merve; Moda, Fabio; Cubo Delgado, Esther PEST-PD is a multi-center project that brings together a multidisciplinary research team composed of neurologists, primary care physicians, physicians specialized in Clinical Analysis and Nuclear Medicine, radiophysicists, biotechnologists, biologists, biostatisticians, agricultural-, telecommunications- and health- engineers, with the aim to understand different aspects of the prevalence of preclinical and prodromal PD in subjects exposed and not exposed to pesticides Póster presentado en: International Congress of Parkinson’s Disease and Movement Disorders, Seoul, Korea, October 4-8, 2026 Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10259/12250 2026-01-01T00:00:00Z