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oai:riubu.ubu.es:10259/100392025-01-25T01:05:30Zcom_10259_6688com_10259_5086com_10259_2604col_10259_6689

Bastard, Paul Rosen, Lindsey B. Zhang, Qian Michailidis, Eleftherios Hoffmann, Hans-Heinrich Zhang, Yu Dorgham, Karim Philippot, Quentin Rosain, Jérémie Béziat, Vivien Manry, Jérémy Shaw, Elana Haljasmägi, Liis Peterson, Pärt Lorenzo, Lazaro Bizien, Lucy Trouillet-Assant, Sophie Dobbs, Kerry de Jesus, Adriana Almeida Belot, Alexandre Kallaste, Anne Catherinot, Emilie Tandjaoui-Lambiotte, Yacine Le Pen, Jeremie Kerner, Gaspard Bigio, Benedetta Seeleuthner, Yoann Yang, Rui Bolze, Alexandre Spaan, András N. Delmonte, Ottavia M. Abers, Michael S. Aiuti, Alessandro Casari, Giorgio Lampasona, Vito Piemonti, Lorenzo Ciceri, Fabio Bilguvar, Kaya Lifton, Richard P. Vasse, Marc Smadja, David M. Migaud, Mélanie Hadjadj, Jérome Terrier, Benjamin Duffy, Darragh Quintana-Murci, Lluis van de Beek, Diederik Roussel, Lucie Vinh, Donald C. Tangye, Stuart G. Haerynck, Filomeen Dalmau, David Martinez-Picado, Javier Brodin, Petter Nussenzweig, Michel C. Boisson-Dupuis, Stéphanie Rodríguez-Gallego, Carlos Vogt, Guillaume Mogensen, Trine H. Oler, Andrew J. Gu, Jingwen Burbelo, Peter D. Cohen, Jeffrey I. Biondi, Andrea Bettini, Laura Rachele D'Angio, Mariella Bonfanti, Paolo Rossignol, Patrick Mayaux, Julien Rieux-Laucat, Frédéric Husebye, Eystein S. Fusco, Francesca Ursini, Matilde Valeria Imberti, Luisa Sottini, Alessandra Paghera, Simone Quiros-Roldan, Eugenia Rossi, Camillo Castagnoli, Riccardo Montagna, Daniela Licari, Amelia Marseglia, Gian Luigi Duval, Xavier Ghosn, Jade Tsang, John S. Goldbach-Mansky, Raphaela Kisand, Kai Lionakis, Michail S. Puel, Anne Zhang, Shen-Ying Holland, Steven M. Gorochov, Guy Jouanguy, Emmanuelle Rice, Charles M. Cobat, Aurélie Notarangelo, Luigi D. Abel, Laurent Su, Helen C. Casanova, Jean-Laurent Arias, Andrés Augusto Boisson, Bertrand Boucherit, Soraya Bustamante, Jacinta Chbihi, Marwa Chen, Jie Chrabieh, Maya Kochetkov, Tatiana Le Voyer, Tom Liu, Dana Nemirovskaya, Yelena Ogishi, Masato Papandrea, Dominick Patissier, Cécile Rapaport, Franck Roynard, Manon Vladikine, Natasha Woollett, Mark Zhang, Peng Kashyap, Anuj Ding, Li Bosticardo, Marita Wang, Qinlu Ochoa, Sebastian Liu, Hui Chauvin, Samuel D. Stack, Michael Koroleva, Galina Bansal, Neha Dalgard, Clifton L. Snow, Andrew L. Abad, Jorge Aguilera-Albesa, Sergio Akcan, Ozge Metin Darazam, Ilad Alavi Aldave, Juan C. Ramos, Miquel Alfonso Nadji, Seyed Alireza Alkan, Gulsum Allardet-Servent, Jerome Allende, Luis M. Alsina, Laia Alyanakian, Marie-Alexandra Amador-Borrero, Blanca Amoura, Zahir Antolí, Arnau Arslan, Sevket Assant, Sophie Auguet, Terese Azot, Axelle Bajolle, Fanny Baldolli, Aurélie Ballester, Maite Feldman, Hagit Baris Barrou, Benoit Beurton, Alexandra Bilbao, Agurtzane Blanchard-Rohner, Geraldine Blanco, Ignacio Blandinières, Adeline Blazquez-Gamero, Daniel Bloomfield, Marketa Bolivar-Prados, Mireia Borie, Raphael Bousfiha, Ahmed A. Bouvattier, Claire Boyarchuk, Oksana Bueno, Maria Rita P. Cáceres Agra, Juan José Calimli, Semra Capra, Ruggero Carrabba, Maria Casasnovas, Carlos Caseris, Marion Castelle, Martin Castelli, Francesco de Vera, Martín Castillo Castro, Mateus V. Chalumeau, Martin Charbit, Bruno Cheng, Matthew P. Clavé, Père Clotet, Bonaventura Codina, Anna Colkesen, Fatih Colkesen, Fatma Colobran, Roger Comarmond, Cloé Corsico, Angelo G. Darley, David Ross Dauby, Nicolas Dauger, Stéphane de Pontual, Loic Dehban, Amin Delplancq, Geoffroy Demoule, Alexandre Di Sabatino, Antonio Diehl, Jean-Luc Dobbelaere, Stephanie Durand, Sophie Eldars, Waleed Elgamal, Mohamed Elnagdy, Marwa H. Emiroglu, Melike Erdeniz, Emine Hafize Aytekin, Selma Erol Euvrard, Romain Evcen, Recep Fabio, Giovanna Faivre, Laurence Falck, Antonin Fartoukh, Muriel Faure, Morgane Arquero, Miguel Fernandez Flores, Carlos Francois, Bruno Fumadó, Victoria Solis, Blanca Garcia Gaussem, Pascale Gil-Herrera, Juana Gilardin, Laurent Alarcon, Monica Girona Girona-Alarcón, Mónica Goffard, Jean-Christophe Gok, Funda González-Montelongo, Rafaela Guerder, Antoine Gul, Yahya Guner, Sukru Nail Gut, Marta Hadjadj, Jérôme Halwani, Rabih Hammarström, Lennart Hatipoglu, Nevin Hernandez-Brito, Elisa Holanda-Peña, María Soledad Horcajada, Juan Pablo Hraiech, Sami Humbert, Linda Iglesias, Alejandro D. Íñigo-Campos, Antonio Jamme, Matthieu Arranz, María Jesús Jordan, Iolanda Kanat, Fikret Kapakli, Hasan Kara, Iskender Karbuz, Adem Yasar, Kadriye Kart Keles, Sevgi Demirkol, Yasemin Kendir Klocperk, Adam Król, Zbigniew J. Kuentz, Paul Kwan, Yat Wah M. Lagier, Jean-Christophe Lau, Yu-Lung Le Bourgeois, Fleur Leo, Yee-Sin Lopez, Rafael Leon Leung, Daniel Levin, Michael Levy, Michael Lévy, Romain Li, Zhi Linglart, Agnes Lorenzo-Salazar, José M. Louapre, Céline Lubetzki, Catherine Luyt, Charles-Edouard Lye, David C. Mansouri, Davood Marjani, Majid Pereira, Jesus Marquez Martin, Andrea Pueyo, David Martínez Marzana, Iciar Mathian, Alexis Matos, Larissa R. B. Matthews, Gail V. 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Alavoine, Loubna Amat, Karine K. A. 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Hafkamp, Florianne Hagens, Laura Hamann, Jorg Harris, Vanessa Hemke, Robert Hermans, Sabine M. Heunks, Leo Hollmann, Markus W. Horn, Janneke Hovius, Joppe W. de Jong, Menno D. Koning, Rutger van Mourik, Niels Nellen, Jeaninne Paulus, Frederique Peters, Edgar van der Poll, Tom Preckel, Benedikt Prins, Jan M. Raasveld, Jorinde Reijnders, Tom Schinkel, Michiel Schultz, Marcus J. Schuurman, Alex Sigaloff, Kim Smit, Marry Stijnis, Cornelis S. Stilma, Willemke Teunissen, Charlotte Thoral, Patrick Tsonas, Anissa van der Valk, Marc Veelo, Denise Vlaar, Alexander P. J. de Vries, Heder van Vugt, Michèle Wiersinga, W. Joost Wouters, Dorien Zwinderman, A. H. (Koos) Al Muhsen, Saleh Al-Mulla, Fahd Anderson, Mark S. Bogunovic, Dusan Bondarenko, Anastasiia Bryceson, Yenan Bustamante, Carlos D. Butte, Manish Chakravorty, Samya Christodoulou, John Cirulli, Elizabeth Condino-Neto, Antonio Cooper, Megan A. DeRisi, Joseph L. Desai, Murkesh Drolet, Beth A. Espinosa, Sara Franco, Jose Luis Gregersen, Peter K. Hagin, David Heath, Jim Henrickson, Sarah E. Hsieh, Elena Imai, Kohsuke Itan, Yuval Karamitros, Timokratis Ku, Cheng-Lung Ling, Yun Lucas, Carrie L. Maniatis, Tom Mansouri, Davoud Marodi, Laszlo Milner, Joshua D. Mironska, Kristina Mogensen, Trine Morio, Tomohiro Novelli, Giuseppe Novelli, Antonio O'Farrelly, Cliona Okada, Satoshi Ozcelik, Tayfun de Diego, Rebeca Perez Planas, Anna M. Prando, Carolina Pujol, Aurora Renia, Laurent Renieri, Alessandra Sancho-Shimizu, Vanessa Sankaran, Vijay Barrett, Kelly Schiabor Shahrooei, Mohammed Snow, Andrew Tangye, Stuart Turvey, Stuart Uddin, Furkan Uddin, Mohammed J. Vazquez, Sara E. von Bernuth, Horst Washington, Nicole Zawadzki, Pawel 2025-01-24T12:00:42Z 2025-01-24T12:00:42Z 2020-09 0036-8075 http://hdl.handle.net/10259/10039 10.1126/science.abd4585 1095-9203 Interindividual clinical vari-ability is vast in humans infected withsevere acute respiratory syndrome corona-virus 2 (SARS-CoV-2), ranging from silent in-fection to rapid death. Three risk factors forlife-threatening coronavirus disease 2019(COVID-19) pneumonia have been identified—being male, being elderly, or having othermedical conditions—but these risk factorscannot explain why critical disease remainsrelatively rare in any given epidemiologicalgroup. Given the rising toll of the COVID-19pandemic in terms of morbidity and mortality,understanding the causes and mechanisms oflife-threatening COVID-19 is crucial. The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, The Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, the Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the Investments for the Future program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANRS-COV05), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, the Institut Institut National de la Santé et de la Recherche Médicale (INSERM), and the University of Paris. Samples from San Raffaele Hospital were obtained through the Covid-BioB project and by healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical laboratory and clinical research unit, funded by the Program Project COVID-19 OSR-UniSR and Fondazione Telethon. The French COVID Cohort Study Group was sponsored by INSERM and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). The Milieu Intérieur Consortium was supported by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence Milieu Intérieur grant (ANR-10-LABX-69-01) (primary investigators: L.Q.-M. and D.Du.). The Simoa experiment was supported by the PHRC-20-0375 COVID-19 grant “DIGITAL COVID” (primary investigator: G.G.). S.G.T. is supported by a Leadership 3 Investigator Grant awarded by the National Health and Medical Research Council of Australia and a COVID19 Rapid Response Grant awarded by UNSW Sydney. C.R.-G. and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry of Science and Innovation RTC-2017-6471-1; AEI/FEDER, UE) and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). S.T.-A. and A.B. were supported by ANR-20-COVI-0064 (primary investigator: A.Be.). This work is supported by the French Ministry of Health “Programme Hospitalier de Recherche Clinique Inter regional 2013,” by the Contrat de Plan Etat-Lorraine and FEDER Lorraine, and by a public grant overseen by the French National Research Agency (ANR) as part of the second Investissements d’Avenir program FIGHT-HF (reference no. ANR-15-RHU-0004) and by the French PIA project “Lorraine Université d’Excellence” (reference no. ANR-15-IDEX-04-LUE) (45); and biobanking is performed by the Biological Resource Center Lorrain BB-0033-00035. This study was supported by the Fonds IMMUNOV, for Innovation in Immunopathology; by a grant from the Agence National de la Recherche (ANR-flash Covid19 “AIROCovid” to F.R.-L.); and by the FAST Foundation (French Friends of Sheba Tel Hashomer Hospital). Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1; a George Mason University Fast Grant; and the G. Harold and Leila Y. Mathers Charitable Foundation. The Amsterdam UMC Covid-19 Biobank was supported by grants from the Amsterdam Corona Research Fund, the Dr. C.J. Vaillant Fund, and the Netherlands Organization for Health Research and Development [ZonMw; NWO-Vici-Grant (grant no. 918·19·627 to D.v.d.B.)]. This work was also supported by the Division of Intramural Research of the National Institute of Dental Craniofacial Research and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Regione Lombardia, Italy (project “Risposta immune in pazienti con COVID-19 e comorbidita”). The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. J.H. holds an Institut Imagine M.D.-Ph.D. fellowship from the Fondation Bettencourt Schueller. J.R. is supported by the INSERM Ph.D. program (“poste d’accueil Inserm”). P.Ba. was supported by the French Foundation for Medical Research (FRM, EA20170638020) and the M.D.-Ph.D. program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). We thank the Association “Turner et vous” for their help and support. Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. D.C.V. is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. K.K. was supported by the Estonian Research Council grant PUT1367. We thank the GEN-COVID Multicenter Study (https://sites.google.com/dbm.unisi.it/gen-covid). We thank the NIAID Office of Cyber Infrastructure and Computational Biology, Bioinformatics and Computational Biosciences Branch (contract no. HHSN316201300006W/HHSN27200002 to MSC, Inc.), the Operations Engineering Branch for developing the HGRepo system to enable streamlined access to the data, and the NCI Advanced Biomedical Computational Science (ABCS) for data transformation support. Biomedical Advanced Research and Development Authority was supported under contract no. HHSO10201600031C (to J.H.). Financial support was provided by the National Institute of Allergy and Infectious Diseases (NIAID) K08AI135091; the Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; and the American Academy of Allergy, Asthma, and Immunology. application/pdf spa American Association for the Advancement of Science Science. 2020, V. 370, n. 6515 https://doi.org/10.1126/science.abd4585 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Medicina Medicine Autoantibodies against type I IFNs in patients with life-threatening COVID-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Science 370 6515