2026-05-14T08:51:32Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/102382025-02-19T01:05:27Zcom_10259_5827com_10259_5086com_10259_2604col_10259_7955
Repositorio Institucional de la Universidad de Burgos
author
Gerardi, Gisela
author
Cavia Saiz, Mónica
author
Muñiz Rodríguez, Pilar
author
López Gámez, Gloria
author
López Bascón, María Asunción
author
Pino García, Raquel del
2025-02-18T09:59:12Z
2025-02-18T09:59:12Z
2023-10
2673-9976
http://hdl.handle.net/10259/10238
10.3390/Foods2023-15018
A functional product obtained from beet molasses vinasse (V) was supplemented to hypertensive rats (SHR) to assess its preventive effects against high blood pressure and endothelial dysfunction. Fifteen potential bioactive compounds (including phenolic acids, flavonoids and terpenoids, and glycosylated compounds) were identified and quantified in V by HPLC-MS. The most notable finding of the study was that the blood pressure values remained similar to those at the beginning of the study in the SHR+V group. At the same time, they increased progressively in the SHR control group, reaching a significant difference of 16% (p < 0.05) after 5 weeks of supplementation. Quantitative PCR and Western blot analyses of the aorta demonstrated that V ingestion by hypertensive rats led to decreased ACE mRNA levels and higher SOD2 and eNOS gene expression via promotion of Nrf2 transcriptional activity and down-regulation of the NF-κB pathway. These results are associated with an increased antioxidant, anti-inflammatory, and vasodilatory response. In conclusion, the intake of vinasse-derived products could mitigate hypertension and associated endothelial dysfunction.
eng
Atribución 4.0 Internacional
Hypertension
Endothelial dysfunction
Oxidative stress
Condensed molasses solubles
Functional foods
Antioxidants
Polyphenols
Redox regulation
Effects of a Functional Product Derived from Beet Molasses Vinasse on Blood Pressure and Endothelial Function in Hypertensive Rats
info:eu-repo/semantics/conferenceObject
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URL
https://riubu.ubu.es/bitstream/10259/10238/1/Gerardi-balsf_2023.pdf
File
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application/pdf
Gerardi-balsf_2023.pdf