2026-09-09T12:05:07Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/105022025-05-28T00:05:24Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

Gómez Gil, Sara Cases, Nuria Hernández Ruiz, Raquel Rubio Presa, Rubén Suárez Pantiga, Samuel Pedrosa Sáez, María de los Remedios Sanz Díez, Roberto 2025-05-27T12:23:29Z 2025-05-27T12:23:29Z 2024-03 1434-193X http://hdl.handle.net/10259/10502 10.1002/ejoc.202400145 1099-0690 We report the efficient, sustainable one-pot synthesis of a wide variety of N-polyheterocycles, such as imidazo-quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction-imine formation-intramolecular cyclization-oxidation sequence. It is worth highlighting that the recycling and incorporation of the waste carbonyl byproduct, generated in the reduction step, into the final compound is realized. In addition, the overall efficiency and atom economy of the process are further improved owing to the participation of one reaction intermediate as reductant that allows lowering the amount of external reducing agent employed. We gratefully acknowledge Ministerio de Ciencia e Innovación (PID2020-115789GB−C21/AEI/10.13039/501100011033), and Junta de Castilla y León and FEDER (BU028P23) for financial support. S.G.-G. thanks Ministerio de Educación for a FPU predoctoral contract. S.S.-P. thanks a Ramón y Cajal (RYC2021-031533-I) contract funded by MCIN/AEI/10.13039/501100011033 and European Union “NextGenerationEU”/PRTR. application/pdf eng Wiley European Journal of Organic Chemistry. 2024, V. 27, n. 18, p. e202400145 https://doi.org/10.1002/ejoc.202400145 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Química Chemistry Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion European Journal of Organic Chemistry 27 18 e202400145