2026-06-19T16:24:50Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/106442026-05-13T09:03:01Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Repositorio Institucional de la Universidad de Burgos
author
Gómez Ayuso, Javier
author
Carreira Barral, Israel
author
Quesada Pato, Roberto
author
García Valverde, María
2025-07-02T08:08:52Z
2025-07-02T08:08:52Z
2025-07
1615-4150
https://hdl.handle.net/10259/10644
10.1002/adsc.202500166
1615-4169
Herein we present a novel one-pot methodology for the synthesis of enantioenriched 2H-pyrrolespirosuccinimides by copper-catalyzed reactions on Ugi adducts derived from enantiopure α-alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen radical-shuttle (HRS) process explains the chemical and stereochemical results. This work demonstrates the efficient stereoselective synthesis of structurally unique, highly functionalized nitrogen heterocyclic systems using simple protocols and affordable starting materials.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Multicomponent reactions
Radical reactions
Copper catalys
Succinimide
Spirosuccinimide
Spiro-2H-pyrrole
Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/10644/1/Gomez-asc_2025.pdf
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URL
https://riubu.ubu.es/bitstream/10259/10644/5/Gomez-asc_2025-sc_supporting_information.pdf
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