2026-06-19T12:56:58Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/106442026-05-13T09:03:01Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

Gómez Ayuso, Javier Carreira Barral, Israel Quesada Pato, Roberto García Valverde, María 2025-07-02T08:08:52Z 2025-07-02T08:08:52Z 2025-07 1615-4150 https://hdl.handle.net/10259/10644 10.1002/adsc.202500166 1615-4169 Herein we present a novel one-pot methodology for the synthesis of enantioenriched 2H-pyrrolespirosuccinimides by copper-catalyzed reactions on Ugi adducts derived from enantiopure α-alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen radical-shuttle (HRS) process explains the chemical and stereochemical results. This work demonstrates the efficient stereoselective synthesis of structurally unique, highly functionalized nitrogen heterocyclic systems using simple protocols and affordable starting materials. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Multicomponent reactions Radical reactions Copper catalys Succinimide Spirosuccinimide Spiro-2H-pyrrole Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions info:eu-repo/semantics/article