2026-10-13T00:29:50Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/109282025-10-07T11:19:39Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

00925njm 22002777a 4500 dc Arunkumar, Guha Asthagiri author Ioannou, Andriani author Wohlbold, Teddy John author Meade, Philip author Aslam, Sadaf author Amanat, Fatima author Ayllón Barasoain, Juan author García Sastre, Adolfo author Krammer, Florian author 2019-03 Protection from influenza virus infection is canonically associated with antibodies that neutralize the virus by blocking the interaction between the viral hemagglutinin and host cell receptors. However, protection can also be conferred by other mechanisms, including antibody-mediated effector functions. Here, we report the characterization of 22 broadly cross-reactive, nonneutralizing antibodies specific for influenza B virus hemagglutinin. The majority of these antibodies recognized influenza B viruses isolated over the period of 73 years and bind the conserved stalk domain of the hemagglutinin. A proportion of the characterized antibodies protected mice from both morbidity and mortality after challenge with a lethal dose of influenza B virus. Activity in an antibody-dependent cell-mediated cytotoxicity reporter assay correlated strongly with protection, suggesting that Fc-dependent effector function determines protective efficacy. The information regarding mechanism of action and epitope location stemming from our characterization of these antibodies will inform the design of urgently needed vaccines that could induce broad protection against influenza B viruses. 0022-538X https://hdl.handle.net/10259/10928 10.1128/JVI.01696-18 1098-5514 ADCC HA Influenza B MAb Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice