2026-10-12T17:22:18Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/109282025-10-07T11:19:39Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863
Repositorio Institucional de la Universidad de Burgos
author
Arunkumar, Guha Asthagiri
author
Ioannou, Andriani
author
Wohlbold, Teddy John
author
Meade, Philip
author
Aslam, Sadaf
author
Amanat, Fatima
author
Ayllón Barasoain, Juan
author
García Sastre, Adolfo
author
Krammer, Florian
2025-10-06T12:02:45Z
2025-10-06T12:02:45Z
2019-03
0022-538X
https://hdl.handle.net/10259/10928
10.1128/JVI.01696-18
1098-5514
Protection from influenza virus infection is canonically associated with antibodies that neutralize the virus by blocking the interaction between the viral hemagglutinin and host cell receptors. However, protection can also be conferred by other mechanisms, including antibody-mediated effector functions. Here, we report the characterization of 22 broadly cross-reactive, nonneutralizing antibodies specific for influenza B virus hemagglutinin. The majority of these antibodies recognized influenza B viruses isolated over the period of 73 years and bind the conserved stalk domain of the hemagglutinin. A proportion of the characterized antibodies protected mice from both morbidity and mortality after challenge with a lethal dose of influenza B virus. Activity in an antibody-dependent cell-mediated cytotoxicity reporter assay correlated strongly with protection, suggesting that Fc-dependent effector function determines protective efficacy. The information regarding mechanism of action and epitope location stemming from our characterization of these antibodies will inform the design of urgently needed vaccines that could induce broad protection against influenza B viruses.
eng
Atribución 4.0 Internacional
ADCC
HA
Influenza B
MAb
Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/10928/1/Asthagiri-jv_2019.pdf
File
MD5
dc8705e2daa1a32e009a5b97f848cefe
1601416
application/pdf
Asthagiri-jv_2019.pdf