2026-06-22T19:35:53Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/112872026-01-27T01:05:58Zcom_10259_4292com_10259_5086com_10259_2604com_10259_5827col_10259_4293col_10259_5828

00925njm 22002777a 4500 dc Ortega Sanz, Irene author Rovira Carballido, Jordi author Megías, Gregoria author Rivero Pérez, Maria Dolores author Melero Gil, Beatriz author 2025-08 The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen. 0882-4010 https://hdl.handle.net/10259/11287 10.1016/j.micpath.2025.107657 Genomics Bacterial GWAS Phenotype Pangenome SNP Genetic marker Genome-Wide association study to identify genetic markers associated with Campylobacter jejuni motility