2026-07-24T16:35:49Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/112872026-01-27T01:05:58Zcom_10259_4292com_10259_5086com_10259_2604com_10259_5827col_10259_4293col_10259_5828
Repositorio Institucional de la Universidad de Burgos
author
Ortega Sanz, Irene
author
Rovira Carballido, Jordi
author
Megías, Gregoria
author
Rivero Pérez, Maria Dolores
author
Melero Gil, Beatriz
2026-01-26T12:55:36Z
2026-01-26T12:55:36Z
2025-08
0882-4010
https://hdl.handle.net/10259/11287
10.1016/j.micpath.2025.107657
The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen.
eng
Atribución-NoComercial 4.0 Internacional
Genomics
Bacterial GWAS
Phenotype
Pangenome
SNP
Genetic marker
Genome-Wide association study to identify genetic markers associated with Campylobacter jejuni motility
info:eu-repo/semantics/article
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URL
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Ortega-mp_2025.pdf