2026-10-12T13:50:09Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/112952026-01-28T01:05:46Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

Fernandez Becerra, Carmen Lelievre, Joel Ferrer, Mireia Antón Fidalgo, Nuria Thomson, Richard Peligero, Cristina Almela, Maria Jesus Lacerda, Marcus VG Herreros, Esperanza del Portillo, Hernando A 2026-01-27T12:42:21Z 2026-01-27T12:42:21Z 2013-09 0074-0276 https://hdl.handle.net/10259/11295 10.1590/0074-0276108062013019 1678-8060 The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+ hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites. application/pdf eng Instituto Oswaldo Cruz, Ministério da Saúde Memórias do Instituto Oswaldo Cruz. 2013, V. 108, n. 6, p. 801-803 https://doi.org/10.1590/0074-0276108062013019 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess CD34+ human haematopoietic stem cells NIH 3T3 cells Plasmodium Hematología Salud Parasitología Hematology Health Parasitology Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Memórias do Instituto Oswaldo Cruz 108 6 801 803