2026-10-13T05:44:49Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/112952026-01-28T01:05:46Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

00925njm 22002777a 4500 dc Fernandez Becerra, Carmen author Lelievre, Joel author Ferrer, Mireia author Antón Fidalgo, Nuria author Thomson, Richard author Peligero, Cristina author Almela, Maria Jesus author Lacerda, Marcus VG author Herreros, Esperanza author del Portillo, Hernando A author 2013-09 The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+ hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites. 0074-0276 https://hdl.handle.net/10259/11295 10.1590/0074-0276108062013019 1678-8060 CD34+ human haematopoietic stem cells NIH 3T3 cells Plasmodium Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection