2026-09-08T04:56:45Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/112972026-01-28T01:05:45Zcom_10259_4862com_10259_5086com_10259_2604col_10259_9974

Biosynthetic rules for marcrolide construction Aparicio Fernández, Jesús Manuel Mendes, Marta V. Antón Fidalgo, Nuria Martín Martín, Juan Francisco Microbiología Bioquímica Microbiology Biochemistry Macrolides constitute a large class of natural metabolites produced by giant multifunctional enzymes in a process resembling fatty acid biosynthesis. Like f atty acids, macrolides and other polyketides are assernbled by decarboxylative condensations of simple carboxylic acids. But while fatty acid intermediates are fully reduced, macrolide and other polyketide intermediates suffer the suppression of reduction or dehydration reactions at given biosynthetic steps. In the last years much progress has 'been made in our understanding of the linear and modular organisation of the gene clusters, and the enzymes encoded by them, responsiblefor... 2026-01-27T12:59:49Z 2026-01-27T12:59:49Z 2002 info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion 81-7736-113-9 9788177361131 https://hdl.handle.net/10259/11297 eng Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation, p. 86-98 https://www.google.es/books/edition/Microbial_Secondary_Metabolites/O0GytAEACAAJ?hl=es info:eu-repo/semantics/closedAccess application/pdf Research Signpost