2026-04-27T12:56:47Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/113352026-02-07T01:05:29Zcom_10259_4363com_10259_5086com_10259_2604col_10259_4364

Sanz Villafruela, Juan 26e36e74-17d9-4c91-ac71-1f07c8a54fa3 600 Carbayo Martín, Mª Aránzazu 99 600 0000-0003-4738-4323 Martínez Alonso, Marta 772 600 0000-0002-0931-5274 Espino Ordóñez, Gustavo 162 600 0000-0001-5617-5705 2026-02-06T12:02:52Z 2026-02-06T12:02:52Z 2025-07 2027-03-14 0010-8545 https://hdl.handle.net/10259/11335 10.1016/j.ccr.2025.216572 Photodynamic therapy (PDT) is a slightly invasive modality of chemotherapy that is arising as a new alternative for the clinical treatment of cancer and other illnesses. This therapy is based on the use of a photosensitiser (PS) which can be activated locally and specifically upon light irradiation to generate reactive oxygen species (ROS) which damage key biomolecules, leading to cancer cell death and tumour regression. This control in the cytotoxicity thanks to the activation of the PS, benefits from a reduction of the undesirable side-effects of the common chemotherapeutics. Among the wide variety of photosensitisers, Ir(III) complexes stand out due to their exceptional photophysical properties and high photostability. In the last years, there have been substantial advances in the development of new Ir(III) scaffolds that have allowed to overcome some of the limitations of PDT and might contribute to a wider clinical development. In this review, we feature the latest and cutting-edge strategies that have been recently employed in the design of new Ir(III) complexes to increase both their light harvesting ability in the therapeutic window and their photodynamic efficiency, to achieve a better biocompatibility, to increase the selectivity towards cancer cells or specific organelles and the possibility of using a combination of PDT with other advanced therapies to enhance the therapeutic effect. The authors gratefully acknowledge financial support from the MCIN/AEI of Spain (PID2021-127187OB-C21). We acknowledge Universidad de Burgos for postdoctoral and predoctoral grants Burgos (M.M.A, 2021/00002/001/001, María Zambrano grant, funded by European Union - NextGenerationEU and J.S.V., 2019/00002/008/001). application/pdf eng Elsevier Coordination Chemistry Reviews. 2025, V. 534, 216572 https://doi.org/10.1016/j.ccr.2025.216572 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess Cyclometalated Ir(III) complexes Medicinal chemistry Anticancer Photodynamic therapy PDT Bioinorganic chemistry Farmacología Oncología Pharmacology Oncology Advanced strategies in the design of Ir(III) biscyclometalated complexes for PDT info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Coordination Chemistry Reviews 534 216572 THUMBNAIL Sanz-ccr_2025.pdf.jpg Sanz-ccr_2025.pdf.jpg IM Thumbnail image/jpeg 4592 https://riubu.ubu.es/bitstream/10259/11335/4/Sanz-ccr_2025.pdf.jpg 1d8544efd793824983a199839afea031 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/11335/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/11335/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Sanz-ccr_2025.pdf Sanz-ccr_2025.pdf application/pdf 2887347 https://riubu.ubu.es/bitstream/10259/11335/1/Sanz-ccr_2025.pdf 944134b46a1a04c73fa6fe35f64a26a4 MD5 1 10259/11335 oai:riubu.ubu.es:10259/11335 2026-02-07 02:05:29.05 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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