2026-05-27T10:22:34Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/117332026-05-27T00:05:40Zcom_10259_3725com_10259_5086com_10259_2604col_10259_3726
Nevado Sánchez, Endika
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600
Rodríguez Díaz, María
e90f8b84-365b-4ab5-8279-6bfa5f739725
600
Núñez Rodríguez, Sandra
20aaeac7-5580-4f1a-a5b4-50dee899cf6c
600
Bueno de la Fuente, Andrea Victoria
b8fdea10-c04b-4c36-bb44-c69a2b88fe41
600
Fuente Anuncibay, Raquel de la
184
600
0000-0002-4535-8570
Villar Suárez, Vega
99cd17d8-9536-4d96-a73c-73ee908019a9
González Bernal, Jerónimo
245
600
0000-0002-7298-9060
Labrador Gómez, Jorge
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600
2026-05-26T12:20:03Z
2026-05-26T12:20:03Z
2025-03
https://hdl.handle.net/10259/11733
10.3390/CELLS14070492
2073-4409
The regenerative potential of mesenchymal stem cell (MSC) secretomes in peripheral nerve injuries warrants rigorous evaluation. This systematic review analyzes their effectiveness in preclinical models of neurotmesis, a complete transection of a nerve. Neurophysiological recovery was assessed through nerve conduction velocity (NCV), a measure of the speed at which electrical impulses travel along a nerve. Following PRISMA guidelines, a systematic search was conducted in PubMed, Scopus, Web of Science, and ScienceDirect (last search July 2024). From 640 initially identified studies, 13 met inclusion criteria, encompassing 514 animals (rats). experimental designs published since 2014 in English or Spanish, focusing on MSC secretomes for nerve regeneration. Exclusion criteria included reviews, case reports, and incomplete data. The risk of bias was assessed using Joanna Briggs Institute tools. Results were synthesized narratively, focusing on functional and structural outcomes. The included studies employed various MSC sources, including adipose tissue, olfactory mucosa, and umbilical cord. Nine studies reported enhanced SFI, favoring secretome-treated groups over controls (mean difference +20.5%, p < 0.01). Seven studies documented increased NCV, with up to 35% higher conduction velocities in treated groups (p < 0.05). Histological outcomes reported in 12 studies showed increased axonal diameter (+25%, p < 0.01), myelin sheath thickness (+30%, p < 0.05), and Schwann cell proliferation. Limitations of the included evidence include methodological heterogeneity and variability in outcome measurement tools. MSC-derived secretomes demonstrate potential as advanced therapeutic strategies for nerve injuries. Personalized approaches considering injury type and clinical context are essential for optimizing outcomes.
application/pdf
eng
MDPI
Cells. 2025. V. 14, n. 7, art. 492
https://doi.org/10.3390/cells14070492
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Secretomes
Stem cells
Nerve regeneration
Neurotmesis
Nerve injuries
Neurofisiología
Neurophysiology
Effectiveness of Stem Cell Secretomes in the Regeneration and Functional Recovery of Severed Nerves in Patients with Nerve Injuries: A Systematic Review
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Cells
14
7
THUMBNAIL
Nevado-Cells-2025.pdf.jpg
Nevado-Cells-2025.pdf.jpg
IM Thumbnail
image/jpeg
4679
https://riubu.ubu.es/bitstream/10259/11733/4/Nevado-Cells-2025.pdf.jpg
c20fdbdefeedf7c41a4b40465638dd8f
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
999
https://riubu.ubu.es/bitstream/10259/11733/3/license.txt
b295bcbce42e2caabeb0c623d3860c06
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
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https://riubu.ubu.es/bitstream/10259/11733/2/license_rdf
0175ea4a2d4caec4bbcc37e300941108
MD5
2
ORIGINAL
Nevado-Cells-2025.pdf
Nevado-Cells-2025.pdf
application/pdf
542285
https://riubu.ubu.es/bitstream/10259/11733/1/Nevado-Cells-2025.pdf
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MD5
1
10259/11733
oai:riubu.ubu.es:10259/11733
2026-05-27 02:05:40.223
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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