2026-06-28T10:04:42Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/118792026-06-27T00:05:22Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210
Repositorio Institucional de la Universidad de Burgos
author
Binacchi, Francesca
author
Cirri, Damiano
author
Bimbi, Eleonora
author
Busto Vázquez, Natalia
author
Pratesi, Alessandro
author
Biver, Tarita
2026-06-26T11:06:06Z
2026-06-26T11:06:06Z
2025-01
0162-0134
https://hdl.handle.net/10259/11879
10.1016/j.jinorgbio.2024.112749
Three Pd(II)-based complexes of 1,10-phenanthroline and N- or O-coordinating ligands have been synthesised and tested with different relevant biosubstrates like double-stranded DNA, double and triple helix of RNA, DNA G-quadruplexes of different conformations and bovine serum albumin. Here a correlation between N- vs O-coordinating elements and binding mechanism emerged, where the N-coordinating ligands proved to be the most promising. These outcomes were confirmed also in the cellular experiments. The Pd(II) complex with naphthalene-1,8-diamine is the one that is able to be carried by BSA, to strongly bind nucleic acids, to produce reactive oxygen species (ROS) and to show the best cellular performances (poorly toxic towards healthy cells and highly toxic against the cisplatin-resistant cancer cell line). On the opposite, the complex with benzene-1,2- diolate may be sequestered by BSA, weakly binds nucleic acids, does not produce ROS and shows poor cellular activity. The complex with benzene-1,2-diamine stays in between. Other mechanistic details are discussed which show that the biophysical behaviour is the sum of the contribution of aromaticity, charge and N- or O-coordination.
eng
Atribución 4.0 Internacional
Metal complexes
Pd(II) cytotoxyc compounds
ROS production
Cancer cell selectivity
Coordination
DNA cleavage
Pd(II)/1,10-phenanthroline complexes bearing arene ligands: On the role of N- vs O-coordination to tune their cellular activity and binding ability towards DNA and RNA
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/11879/1/Binacchi-JoIB_2025.pdf
File
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Binacchi-JoIB_2025.pdf