2026-07-11T18:27:05Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/118942026-07-03T00:05:26Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria Marco, Alicia Vigueras, Gloria Busto Vázquez, Natalia Cutillas, Natalia Bautista, Delia Ruiz, José Química inorgánica Chemistry Inorganic New valproate Ir(III) and Rh(III) half-sandwich conjugates containing a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The valproic acid conjugation to organometallic fragments seems to switch on the antibacterial activity of the complexes towards Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria. This work was supported by funds from the Spanish Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación (MCI/AEI/10.13039/501100011033) and FEDER funds (Project PID2021-122850NB-I00) and Fundación Séneca-CARM (project 21989/PI/22), Consejería de Educación-Junta de Castilla y León-FEDER (BU305P18) and “la Caixa” Banking Foundation (LCF/PR/PR12/11070003). G. V. thanks the University of Murcia for a grant (R-1034/2016). A. M. thanks Fundación Séneca-Región de Murcia for a grant (project 21234/FPI/19). 2026-07-02T10:49:00Z 2026-07-02T10:49:00Z 2023-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1477-9226 https://hdl.handle.net/10259/11894 10.1039/d3dt01678a 1477-9234 eng Dalton Transactions. 2023, V. 52, n. 38, p. 13482-13486 https://doi.org/10.1039/d3dt01678a Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Royal Society of Chemistry