2026-07-11T18:29:05Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/119072026-07-09T00:05:22Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210
Simón Vicente, Lucía
635
600
0000-0003-4450-7316
Rivadeneyra Posadas, Jéssica Jannett
8b6474c8-2c4f-445f-95e6-70a0b79f5a5f
600
Mariscal, Natividad
e5bc8958-976e-4cb3-9241-2036a63603ed
600
Aguado, Laura
e07b48f3-0137-4942-a4c7-dd0fdbc79d1f
600
Miguel-Pérez, Irene
d6aa23d4-2584-4460-8fe4-3f96443351e3
600
Saiz Rodríguez, Miriam
826
600
0000-0002-1660-3135
García Bustillo, Álvaro
889
600
0000-0003-2561-1003
Muñoz-Siscart, Ignacio
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600
Díaz-Piñeiro, Dolores
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600
Cubo Delgado, Esther
131
600
0000-0003-0018-1182
2026-07-08T11:34:30Z
2026-07-08T11:34:30Z
2024-12
2077-0383
https://hdl.handle.net/10259/11907
10.3390/jcm14010168
Background/Objectives: Huntington’s disease (HD) is a neurodegenerative movement disorder associated with significant disability and impairment of Activities of Daily Living (ADLs). The impact of upper limb disability on quality of life (QoL) and its influence on ADLs is not well known yet. The aim of this study was to describe the manipulative dexterity, strength, and manual eye coordination of patients with manifest
and premanifest-HD compared to healthy individuals and to analyze its influence on ADLs and QoL. Methods: We performed an observational, cross-sectional study including 71 ambulatory participants (27 manifest-HD patients, 15 premanifest-HD, and 29 controls). We gathered sociodemographic data, as well as clinical data, including cognition (MMSE), HD motor severity (Unified HD rating scale, UHDRS-TMS), QoL (Neuro-QoL), and ADLs (HD-ADL). Hand dexterity and strength in the dominant and non-dominant hand were assessed with the Nine Hole Peg Test, Ten Neurotest, Nut and Bolt Test, dynamometry, and Late-Life FDI. Analysis of covariance (ANCOVA) models were performed to investigate differences in hand function between manifest-HD, premanifest-HD, and controls. Results: Manifest-HD patients had significantly worse performance in manual and finger dexterity, fine-motor coordination, and poorer handgrip strength than premanifest-HD and controls. Premanifest-HD required more time to complete the test than controls. Significant correlations were found between hand variables and Late-Life FDI, Neuro-QoL, HD-ADL, and UHDRS-TMS. Conclusions: HD affects manipulative dexterity and hand function in
premanifest and manifest patients. Therefore, to prevent disability and decreased QoL, evaluating the progression of upper limb dysfunction in HD is important to offer the best possible therapeutic interventions.
eng
MDPI
Journal of Clinical Medicine. 2025, V. 14, n. 1, art. 168
https://doi.org/10.3390/jcm14010168
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Activities of daily living
Manipulative dexterity
Hand
Huntington’s disease
Enfermedad de Huntington
Trastornos motores
Huntington's disease
Movement disorders
Impact of Upper Limb Function on Activities of Daily Living and Quality of Life in Huntington’s Disease
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Journal of Clinical Medicine
14
1
THUMBNAIL
Simon-CM_2025.pdf.jpg
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license.txt
license.txt
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Simon-CM_2025.pdf
Simon-CM_2025.pdf
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10259/11907
oai:riubu.ubu.es:10259/11907
2026-07-09 02:05:22.472
Repositorio Institucional de la Universidad de Burgos
bubrep@ubu.es
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