2026-07-11T18:27:46Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/119092026-07-10T00:05:23Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210

Cubo Delgado, Esther 131 600 0000-0003-0018-1182 Rivadeneyra Posadas, Jéssica Jannett 8b6474c8-2c4f-445f-95e6-70a0b79f5a5f 600 Simón Vicente, Lucía 635 600 0000-0003-4450-7316 Aguado, Laura e07b48f3-0137-4942-a4c7-dd0fdbc79d1f 600 Calvo Simal, Sara 825 600 Saiz Rodríguez, Miriam 826 600 0000-0002-1660-3135 Mariscal, Natividad e5bc8958-976e-4cb3-9241-2036a63603ed 600 Muñoz-Siscart, Ignacio 0222c8db-041c-41f1-99b3-69abfb0440d9 600 Díaz-Piñeiro, Dolores 048d37b8-6551-4432-ace5-0e922b2a92be 600 Miguel-Pérez, Irene d6aa23d4-2584-4460-8fe4-3f96443351e3 600 Gámez-Leyva, G. 3ad84015-7644-4d14-abc8-e873c029b3d5 García Bustillo, Álvaro 889 600 0000-0003-2561-1003 Martínez-Descalls, A. f8a1b8b0-0a3b-4fc3-b73c-ed7143a61ee0 2026-07-09T11:05:32Z 2026-07-09T11:05:32Z 2025-07 0213-4853 https://hdl.handle.net/10259/11909 10.1016/j.nrl.2024.01.001 Introduction: Despite the wealth of evidence suggesting a protective role of lifestyle factors on Huntington’s disease (HD) onset and progression, their association with mortality has not been extensively studied. The aim of this study was to examine whether lifestyle factors such as caffeine and alcohol consumption, smoking, physical activity level, and Mediterranean diet (MeDi) adherence are associated with mortality among a Spanish cohort of patients with HD with a 9-year surveillance period. Methods: This national study was performed using a nested, observational, longitudinal design. We included subjects diagnosed with HD who participated in the European Huntington’s disease network and Enrol-HD studies. Date of death and baseline lifestyle factor information, demographics, disease severity assessed by the Unified Huntington’s Disease Rating Scale (UHDRS), Problem Behaviours Assessment, total functional capacity (TFC) scores, and comorbidities were collected. Adjusted Cox proportional hazards models were conducted to determine the association of lifestyle factors with mortality. Results: We included 87 patients (52 females) with a mean age of 48.62 ± 14.43 years and CAG repeats of 43.76 ± 5.92. Sixteen deaths were recorded. After correcting for multiple comparisons, deceased patients had higher UHDRS scores at baseline and lower caffeine consumption than live patients. In multivariate Cox regression models, after adjusting for age, CAG repeats, and TFC, mortality risk was associated with lower caffeine consumption (HR 0.13, 95% CI 0.04, 0.45). This work was partially supported by the European Hunting-ton Disease Network (EHDN, Seed Fund 338) and by Nutriciaand Advanced Medical Nutrition Fresenius-Kabi Pharmaceu-ticals. Data were analyzed independently by the fundingsources. eng Elsevier Neurología. 2025, V. 40, n. 4, p. 361-371 https://doi.org/10.1016/j.nrl.2024.01.001 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Huntington’s disease Chorea Mortality Survival Lifestyle factors Enfermedad de Huntington Huntington's disease The association between lifestyle factors and mortality in Huntington's disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Neurología 40 4 361 371 THUMBNAIL Cubo-Neurología_2025.pdf.jpg Cubo-Neurología_2025.pdf.jpg IM Thumbnail image/jpeg 3672 https://riubu.ubu.es/bitstream/10259/11909/4/Cubo-Neurolog%c3%ada_2025.pdf.jpg 328895eccc0c99d44a3f3050dcf29935 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/11909/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/11909/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Cubo-Neurología_2025.pdf Cubo-Neurología_2025.pdf application/pdf 1192697 https://riubu.ubu.es/bitstream/10259/11909/1/Cubo-Neurolog%c3%ada_2025.pdf 75286840cf945954de22d245ee16af3e MD5 1 10259/11909 oai:riubu.ubu.es:10259/11909 2026-07-10 02:05:23.903 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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