2026-07-18T20:34:08Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/119192026-07-17T00:05:26Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210

Sanz-Solas, Antonio Labrador, Jorge Alcaraz, Raquel Cuevas, Beatriz Vinuesa, Raquel Cuevas, María Victoria Saiz-Rodríguez, Miriam 2026-07-16T11:27:01Z 2026-07-16T11:27:01Z 2023-04 2075-4426 https://hdl.handle.net/10259/11919 10.3390/jpm13040695 Multiple myeloma (MM) is a hematological neoplasm for which different chemotherapy treatments are used with several drugs in combination. One of the most frequently used drugs for the treatment of MM is the proteasome inhibitor bortezomib. Patients treated with bortezomib are at increased risk for thrombocytopenia, neutropenia, gastrointestinal toxicities, peripheral neuropathy, infection, and fatigue. This drug is almost entirely metabolized by cytochrome CYP450 isoenzymes and transported by the efflux pump P-glycoprotein. Genes encoding both enzymes and transporters involved in the bortezomib pharmacokinetic pathway are highly polymorphic. The response to bortezomib and the incidence of adverse drug reactions (ADRs) vary among patients, which could be due to interindividual variations in these possible pharmacogenetic biomarkers. In this review, we compiled all pharmacogenetic information relevant to the treatment of MM with bortezomib. In addition, we discuss possible future perspectives and the analysis of potential pharmacogenetic markers that could influence the incidence of ADR and the toxicity of bortezomib. It would be a milestone in the field of targeted therapy for MM to relate potential biomarkers to the various effects of bortezomib on patients. A.S.-S. contract was funded by Fundación hna, 2nd edition of the Scientific Health Research Award. M.S.-R. contract was supported by Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Science and Innovation, through the Sara Borrell Program (CD21/00022). eng MDPI Journal of Personalized Medicine. 2023, V.13, n. 4, art. 695 https://doi.org/10.3390/jpm13040695 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Multiple myeloma Bortezomib Toxicity Efficacy Pharmacogenetic biomarkers Farmacogenómica Pharmacogenomics Bortezomib Pharmacogenetic Biomarkers for the Treatment of Multiple Myeloma: Review and Future Perspectives info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Personalized Medicine 13 4