2026-09-09T12:09:56Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/119242026-07-18T00:05:28Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210

Zubiaur, Pablo e32e4997-27e8-492f-b14a-9a7c7fe226a9 600 Saiz Rodríguez, Miriam 826 600 0000-0002-1660-3135 Abad‐Santos, Francisco 788d0f1b-77ee-4bb0-ab59-203c90c38a44 600 2026-07-17T11:26:53Z 2026-07-17T11:26:53Z 2023-01 0753-3322 https://hdl.handle.net/10259/11924 10.1016/j.biopha.2022.114003 On August 12, 2022, Biomedicine and Pharmacotherpy published a systematic review on the pharmacogenetics of siponimod by Díaz-Villamarín et al. [1] We would like to acknowledge the work done by the authors, as siponimod is a drug that may occupy a priority place in the management of secondarily progressive multiple sclerosis (SPMS) with active disease evidenced by relapses or imaging features of inflammatory activity. Therefore, we believe that research aimed at clarifying the impact of genetic variants on the effectiveness and safety of this drug is needed; therefore, we applaud the authors’ efforts with this systematic review. We consider that there are several inconsistencies in the therapeutic recommendations contained in the siponimod drug label and in those issued by the two most relevant international associations in pharmacogenetics: the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG). P. Zubiaur is financed by Universidad Autónoma de Madrid, Margarita Salas contract, grants for the requalification of the Spanish university system. eng Elsevier Biomedicine & Pharmacotherapy. 2023, V. 157, art. 114003 https://doi.org/10.1016/j.biopha.2022.114003 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Pharmacogenetics Siponimod Secondarily progressive multiple sclerosis (SPMS) Farmacogenómica Esclerosis múltiple Pharmacogenomics Multiple sclerosis “Pharmacogenetics of siponimod: A systematic review” by Díaz-Villamarín et al. – Information is power info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Biomedicine & Pharmacotherapy 157 THUMBNAIL Zubiaur-BM_2023.pdf.jpg Zubiaur-BM_2023.pdf.jpg IM Thumbnail image/jpeg 5109 https://riubu.ubu.es/bitstream/10259/11924/4/Zubiaur-BM_2023.pdf.jpg 841274311f41627cf17f3a3712359daa MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/11924/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 908 https://riubu.ubu.es/bitstream/10259/11924/2/license_rdf 0175ea4a2d4caec4bbcc37e300941108 MD5 2 ORIGINAL Zubiaur-BM_2023.pdf Zubiaur-BM_2023.pdf application/pdf 411593 https://riubu.ubu.es/bitstream/10259/11924/1/Zubiaur-BM_2023.pdf 48e5c6112906aee974ca58ac57e4d6ab MD5 1 10259/11924 oai:riubu.ubu.es:10259/11924 2026-07-18 02:05:28.318 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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