2026-07-24T11:33:01Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/119252026-07-20T07:58:10Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210

García-Alfonso, P. Saiz Rodríguez, Miriam Mondéjar, R. Salazar, J. Páez, D. Borobia, A. M. Safont, M. J. García-García, I. Colomer, R. García-González, X. Herrero, M. J. López-Fernández, L. A. Abad-Santos, F. 2026-07-17T11:43:27Z 2026-07-17T11:43:27Z 2022-03 1699-048X https://hdl.handle.net/10259/11925 10.1007/s12094-021-02708-4 1699-3055 5-Fluorouracil (5-FU) and oral fluoropyrimidines, such as capecitabine, are widely used in the treatment of cancer, especially gastrointestinal tumors and breast cancer, but their administration can produce serious and even lethal toxicity. This toxicity is often related to the partial or complete deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme, which causes a reduction in clearance and a longer half-life of 5-FU. It is advisable to determine if a DPD deficiency exists before administering these drugs by genotyping DPYD gene polymorphisms. The objective of this consensus of experts, in which representatives from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology participated, is to establish clear recommendations for the implementation of genotype and/or phenotype testing for DPD deficiency in patients who are candidates to receive fluoropyrimidines. The genotyping of DPYD previous to treatment classifies individuals as normal, intermediate, or poor metabolizers. Normal metabolizers do not require changes in the initial dose, intermediate metabolizers should start treatment with fluoropyrimidines at doses reduced to 50%, and poor metabolizers are contraindicated for fluoropyrimidines. This project has been financed with SEOM and SEFF resources. eng Springer Nature Clinical and Translational Oncology. 2022, V. 24, n. 3, p. 483-494 https://doi.org/10.1007/s12094-021-02708-4 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 5-fluorouracil Capecitabine Dihydropyrimidine dehydrogenase Genotypes Pharmacogenetics Toxicity Farmacogenómica Pharmacogenomics Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Clinical and Translational Oncology 24 3 483 494