2026-07-24T11:32:55Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/119252026-07-20T07:58:10Zcom_10259_11209com_10259_5086com_10259_2604col_10259_11210
Repositorio Institucional de la Universidad de Burgos
author
García-Alfonso, P.
author
Saiz Rodríguez, Miriam
author
Mondéjar, R.
author
Salazar, J.
author
Páez, D.
author
Borobia, A. M.
author
Safont, M. J.
author
García-García, I.
author
Colomer, R.
author
García-González, X.
author
Herrero, M. J.
author
López-Fernández, L. A.
author
Abad-Santos, F.
2026-07-17T11:43:27Z
2026-07-17T11:43:27Z
2022-03
1699-048X
https://hdl.handle.net/10259/11925
10.1007/s12094-021-02708-4
1699-3055
5-Fluorouracil (5-FU) and oral fluoropyrimidines, such as capecitabine, are widely used in the treatment of cancer, especially gastrointestinal tumors and breast cancer, but their administration can produce serious and even lethal toxicity. This toxicity is often related to the partial or complete deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme, which causes a reduction in clearance and a longer half-life of 5-FU. It is advisable to determine if a DPD deficiency exists before administering these drugs by genotyping DPYD gene polymorphisms. The objective of this consensus of experts, in which representatives from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology participated, is to establish clear recommendations for the implementation of genotype and/or phenotype testing for DPD deficiency in patients who are candidates to receive fluoropyrimidines. The genotyping of DPYD previous to treatment classifies individuals as normal, intermediate, or poor metabolizers. Normal metabolizers do not require changes in the initial dose, intermediate metabolizers should start treatment with fluoropyrimidines at doses reduced to 50%, and poor metabolizers are contraindicated for fluoropyrimidines.
eng
Atribución 4.0 Internacional
5-fluorouracil
Capecitabine
Dihydropyrimidine dehydrogenase
Genotypes
Pharmacogenetics
Toxicity
Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/11925/1/Garc%c3%ada-CTO_2022.pdf
File
MD5
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application/pdf
García-CTO_2022.pdf