2026-10-09T01:06:56Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/122372026-10-08T00:05:28Zcom_10259_6168com_10259_5086com_10259_2604col_10259_12236

ERK dimerization promotes tumorigeneses in breast cancer ERK dimerization promotes migration in breast cancer Fuente Vivas, Dalia de la Casar, Berta Crespo, Piero Mamas-Cáncer Metástasis Breast-Cancer Póster y resumen presentado en: 27th Porto Cancer Meeting "Stemness & Metastasis: Advances in Research and Clinical Translation" held online on 20-21 May 2021 Activation of the Ras-ERK signaling cascade is associated with increased metastasis risk inbreast cancer. In the present study. ERK dimerization plays a crucial role in the migrationand invasion of breast tumor cells. ERK dimers bind to the scaffold protein KSR1 toenhance migration. Blocking ERK dimers formation reduced invasion capacity of MCF-7and MDA-231-MB tumors cells. Thus, targeting ERK dimerization could emerge as a validtherapeutic strategy for the treatment of breast cancer. 2026-10-07T07:23:34Z 2026-10-07T07:23:34Z 2021 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/acceptedVersion https://hdl.handle.net/10259/12237 eng info:eu-repo/semantics/openAccess application/pdf