2026-10-09T03:10:42Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/122452026-10-08T00:05:34Zcom_10259_6168com_10259_5086com_10259_2604col_10259_12236

Toxicologial Evaluation of Pristine MXene, PolyPyrrole Functionalized MXene, and MXene-Graphene Hybrids Using Cellular and Computational Models Fuente Vivas, Dalia de la Huerta Sainz, Sergio de la Rodriguez-Vinagre, J. Palacios Santamaría, David Aparicio Martínez, Santiago Gómez Cuadrado, Laura MXenes Safe-and-Sustainable-by-Design (SSbD) New Approach Methodologies (NAMs) QSAR 3D spheroids Nanotoxicology Materiales nanoestructurados Toxicología Nanostructured materials Toxicology Póster presentado a: 23 International Congress ESTIV, Maastricht, 2026, 29 june - 2 july Background: MXenes and Graphene possess outstanding physicochemical properties (thermal stability, electrical conductivity). They have strong application potential in biosensors, conductive ink, and EMI shielding. Challenge: Current (nano)particle regulations present critical gaps, particularly in human health risk assessment. There is a growing need for Safe by Design (SbD) aligned evaluation strategies. Aim: Implementing NAMs (in vitro and in silico) to replace animal testing and effectively bridge the in vitro-in vivo gap in safety assessments. Approach: Step-1 SbD was implemented via chemical hazard identification. In vitro NAMs (static and dynamic 3D spheroids) were compared with 2D cultures in a multi-tiered approach integrating toxicological profiles with predictive in silico models for mechanistic cellular analysis. Impact: Enables SbD-driven, animal-free predictive toxicology by integrating advanced 3D NAMs with in silico mechanistic modeling. The SAFARI – Safe and Sustainable by Design Graphene/MXenes Hybrids project has received funding from the European Union’s Horizon Europe research and innovation programme under Grant Agreement No. 101135965. 2026-10-07T12:44:21Z 2026-10-07T12:44:21Z 2026 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/acceptedVersion https://hdl.handle.net/10259/12245 eng info:eu-repo/semantics/openAccess application/pdf