2026-10-29T16:09:49Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/123042026-10-28T01:05:25Zcom_10259_4363com_10259_5086com_10259_2604col_10259_4364

Amiri Rudbari, Hadi b2990e32-ba5f-4dc8-bfa7-bcb525b5496f 600 Kazemi, Zahra 820e34aa-019c-4d21-bfb8-755085f0fda6 Nicosia, Angelo e4e9e60e-33e3-4f00-bda4-79df1399e7da Mineo, Placido 7fe89283-5fa5-4812-9531-7629c823d67d Riera, Chiara 808c204b-e6ab-42df-902c-b79ecabcb9de Rossi, Arianna c8894e0f-8d90-424b-a20b-ae89cfb30753 Montesi, Monica 75c563a3-743f-4e60-8634-903f067b219a Panseri, Silvia 58f5794a-5be0-48f3-9800-36001c73aaa1 Di Pietro, Maria Letizia 1f312a82-be0e-4b81-b056-a3102a5827f8 Iraci, Nunzio c30f1343-80f3-4a22-99eb-c00a84508afa 600 Stagno, Claudio 11edaefd-0d1a-4495-a423-6e35ddda9447 600 Sorace, Lorenzo 0efd0a67-6b66-4a87-b031-eed7193d8d01 Cuevas Vicario, José Vicente 137 600 0000-0002-2421-1529 Micale, Nicola 7664fb9b-6787-4f68-8759-e5e0263a6aa6 2026-10-27T08:38:55Z 2026-10-27T08:38:55Z 2026-12 1387-7003 https://hdl.handle.net/10259/12304 10.1016/j.inoche.2026.117734 A comprehensive panel of mixed ligand Cu(II)-complexes with general formula Cu(X-dppz)(X2-sal)(NO3) was synthesized and properly characterized through elemental analysis, FT-IR, mass spectrometry, UV–Vis and EPR spectroscopy. Theoretical calculations using DFT and TD-DFT methods were carried out to support the interpretation of the absorption spectra, revealing that most of the observed absorptions exhibit either Ligand Centered (LC) or Ligand-to-Ligand Charge Transfer (LLCT) character. The study was aimed to investigate them as anticancer agents against three cancer cell lines selected based on the incidence (MDA-MB 231) and aggressiveness (U87 and MG 63) of the related tumor type, and to investigate the effect of substitutions on both ligands (i.e., the polypyridyl diimine ligand, dppz, and the auxiliary ligand, sal) on antiproliferative activities of the complexes. The results showed that complexes bearing the –NO₂ group on the dppz ligand exhibited significantly higher cytotoxicity, particularly against MDA-MB 231 cells, compared to their Cl-substituted counterparts, with the exception of the complex with the 3-bromo-5-chloro-salicylaldehyde as auxiliary ligand. The latter also turned out to be essential for the cytotoxicity (comparative analysis with sal-free Cu(II)-complexes) as well as the complete structure of the complexes (comparative analysis with pure polypyridyl ligands). Mechanistic studies (in vitro and in silico) revealed that these complexes induce cytotoxicity through Reactive Oxygen Species (ROS) generation and intercalation into the DNA double helix, as well as through G-quadruplex stabilization. Among the synthesized compounds, complexes Cl2CuBrCl (4) and NO2CuBrCl (14) demonstrated the most promising biological activity, making them compelling candidates for further investigation as anticancer agents. application/pdf eng Elsevier Inorganic Chemistry Communications. 2026, V. 194, 117734 https://doi.org/10.1016/j.inoche.2026.117734 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Copper complexes Cancer ROS DNA-intercalation G-quadruplex stabilization Compuestos complejos Cáncer Complex compounds Cancer Development of Cu(II) complexes of substituted polypyridyl and salicylaldehyde ligands as anticancer agents info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Inorganic Chemistry Communications 194 THUMBNAIL Rudbari-icc_2026.pdf.jpg Rudbari-icc_2026.pdf.jpg IM Thumbnail image/jpeg 4868 https://riubu.ubu.es/bitstream/10259/12304/4/Rudbari-icc_2026.pdf.jpg 0cdc1d079a2c79e4d1bc9de4f4202de7 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 998 https://riubu.ubu.es/bitstream/10259/12304/3/license.txt aa90105e1c90a1b4fe810649aa967b7d MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 914 https://riubu.ubu.es/bitstream/10259/12304/2/license_rdf 24013099e9e6abb1575dc6ce0855efd5 MD5 2 ORIGINAL Rudbari-icc_2026.pdf Rudbari-icc_2026.pdf application/pdf 8610326 https://riubu.ubu.es/bitstream/10259/12304/1/Rudbari-icc_2026.pdf 598067a7ebed3af1026e60122d728036 MD5 1 10259/12304 oai:riubu.ubu.es:10259/12304 2026-10-28 02:05:25.501 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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