2026-04-28T22:10:17Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/35332024-07-18T09:38:39Zcom_10259_9433com_10259_5087com_10259_2728col_10259_9434

Puesta a punto de un biosensor para la determinación de analitos de interés en el tratamiento de trastornos depresivos: detección electroquímica de imipramina Sancho Querol, Sara Domínguez Renedo, Olga Universidad de Burgos. Departamento de Química Química analítica Chemistry, Analytic This work reports the development of two different sensors using screen-printed carbon electrodes (SPCEs) for the determination of imipramine (IMP) by differential pulse voltammetry. On one hand, a bare SPCE has been successfully applied to the determination of this compound and, on the other hand, the modification of this SPCE with metallic gold nanoparticles (AuNPs/SPCE) have led to an increase in the sensitivity of IMP determination. Both sensors have been characterized obtaining good capability of detection (14.1 μM and 0.28 μM for SPCE and AuNPs/SPCE, respectively) and reproducibility (4.75 % and 6.87 % for SPCE and AuNPs/SPCE, respectively) values. The specificity of both sensors towards different compounds has been also analyzed and, the developed electrochemical systems have been successfully applied in the determination of IMP in commercial pharmaceutical preparations. 2014-10-21T10:06:26Z 2014-10-21T10:06:26Z 2014 info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/10259/3533 spa Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Este documento está sujeto a una licencia de uso Creative Commons, por la cual está permitido hacer copia, distribuir y comunicar públicamente la obra siempre que se cite al autor original y no se haga de él uso comercial ni obra derivada info:eu-repo/semantics/openAccess application/pdf