2026-04-29T03:35:24Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/35332024-07-18T09:38:39Zcom_10259_9433com_10259_5087com_10259_2728col_10259_9434

Puesta a punto de un biosensor para la determinación de analitos de interés en el tratamiento de trastornos depresivos: detección electroquímica de imipramina Sancho Querol, Sara Domínguez Renedo, Olga This work reports the development of two different sensors using screen-printed carbon electrodes (SPCEs) for the determination of imipramine (IMP) by differential pulse voltammetry. On one hand, a bare SPCE has been successfully applied to the determination of this compound and, on the other hand, the modification of this SPCE with metallic gold nanoparticles (AuNPs/SPCE) have led to an increase in the sensitivity of IMP determination. Both sensors have been characterized obtaining good capability of detection (14.1 μM and 0.28 μM for SPCE and AuNPs/SPCE, respectively) and reproducibility (4.75 % and 6.87 % for SPCE and AuNPs/SPCE, respectively) values. The specificity of both sensors towards different compounds has been also analyzed and, the developed electrochemical systems have been successfully applied in the determination of IMP in commercial pharmaceutical preparations. info:eu-repo/semantics/bachelorThesis spa http://hdl.handle.net/10259/3533 https://riubu.ubu.es/bitstream/10259/3533/1/Sancho_Querol.pdf f45300ddbd866704d17b28f28ae36a4d https://riubu.ubu.es/bitstream/10259/3533/5/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 https://riubu.ubu.es/bitstream/10259/3533/6/Sancho_Querol.pdf.txt 4dd0464b97c248a7cf2023d06e8f97e6 Attribution-NonCommercial-NoDerivatives 4.0 International Química analítica Chemistry, Analytic