2026-05-30T19:04:14Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/39092021-11-10T09:38:19Zcom_10259_3593com_10259_5086com_10259_2604com_10259_3924col_10259_3594col_10259_3925
A Practical, One-Pot Synthesis of Highly Substituted Thiophenes and Benzo[b]thiophenes from Bromoenynes and o-Alkynylbromobenzenes
Guilarte Moreno, Verónica
Fernández Rodríguez, Manuel A.
García García, Patricia
Hernando Santa Cruz, Elsa
Sanz Díez, Roberto
An efficient synthesis of thiophenes and benzo[b]thiophenes has been developed from easily available bromoenynes and o-alkynylbromobenzene derivatives. This novel one-pot procedure involves a Pd-catalyzed C–S bond formation using a hydrogen sulfide surrogate followed by a heterocyclization reaction. Moreover, in situ functionalization with selected electrophiles further expands the potential of this methodology to the preparation of the corresponding highly substituted sulfur heterocycles.
2016-01-21
2016-01-21
2011-09
info:eu-repo/semantics/article
1523-7060
http://hdl.handle.net/10259/3909
10.1021/ol201970m
eng
Organic Letters. 2011. V. 13, n. 19, p. 5100-5103
http://dx.doi.org/10.1021/ol201970m
info:eu-repo/grantAgreement/MICINN/CTQ2010-15358
info:eu-repo/grantAgreement/MICINN/CTQ2009-09949/BQU
info:eu-repo/grantAgreement/JCyL/BU021A09
info:eu-repo/grantAgreement/JCyL/GR-172
info:eu-repo/semantics/openAccess
American Chemical Society