2026-06-17T21:36:05Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/39132025-04-22T10:06:25Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594
Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles
Guilarte Moreno, Verónica
Castroviejo Fernández, Mª Pilar
García García, Patricia
Fernández Rodríguez, Manuel A.
Sanz Díez, Roberto
2,3-Dihaloanilines have been proved as useful
starting materials for synthesizing 4-halo-1H-indoles. Subsequent
or in situ functionalization of the prepared haloindoles
allows the access to a wide variety of 2,4- or 2,3,4-regioselectively
functionalized indoles in good overall yields. As no
efficient synthetic routes to 2,3-dihaloanilines have been described
in the literature, different approaches to the preparation
of these 1,2,3-functionalized aromatic precursors are now
presented. The most general one involves a Smiles rearrangement
from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and
synthetically useful manner.
2016-01-27
2016-01-27
2011-03
info:eu-repo/semantics/article
0022-3263
http://hdl.handle.net/10259/3913
10.1021/jo200406f
eng
Journal of organic chemistry. 2010. V. 76, n. 9, p. 3416–3437
http://dx.doi.org/10.1021/jo200406f
info:eu-repo/grantAgreement/MICINN-FEDER/CTQ2010-15358
info:eu-repo/grantAgreement/JCyL/BU021A09
info:eu-repo/grantAgreement/JCyL/GR-172
info:eu-repo/semantics/openAccess
American Chemical Society