2026-04-29T09:14:00Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/39132025-04-22T10:06:25Zcom_10259_3593com_10259_5086com_10259_2604col_10259_3594

00925njm 22002777a 4500 dc Guilarte Moreno, Verónica author Castroviejo Fernández, Mª Pilar author García García, Patricia author Fernández Rodríguez, Manuel A. author Sanz Díez, Roberto author 2011-03 2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner. 0022-3263 http://hdl.handle.net/10259/3913 10.1021/jo200406f Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles