2026-08-23T15:39:56Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/43592022-04-29T12:02:48Zcom_10259_4313com_10259_5086com_10259_2604com_10259_4365col_10259_4314col_10259_4366

Vallejos Calzada, Saúl Estévez Bolívar, Pedro Antonio Ibeas Cortes, Saturnino García García, Félix Clemente Serna Arenas, Felipe García Pérez, José Miguel 2017-03-14T09:48:16Z 2017-03-14T09:48:16Z 2012-03 1424-8220 http://hdl.handle.net/10259/4359 10.3390/s120302969 The preparation of a fluorogenic sensory material for the detection of biomolecules is described. Strategic functionalisation and copolymerisation of a water insoluble organic sensory molecule with hydrophilic comonomers yielded a crosslinked, water-swellable, easy-to-manipulate solid system for water ‘‘dip-in’’ fluorogenic coenzyme A, cysteine, and glutathione detection by means of host-guest interactions. The sensory material was a membrane with gel-like behaviour, which exhibits a change in fluorescence behaviour upon swelling with a water solution of the target molecules. The membrane follows a “turn-on” pattern, which permits the titration of the abovementioned biomolecules. In this way, the water insoluble sensing motif can be exploited in aqueous media. The sensory motif within the membrane is a chemically anchored piperazinedione-derivative with a weakly bound Hg(II). The response is caused by the displacement of the cation from the membrane due to a stronger complexation with the biomolecules, thus releasing the fluorescent sensory moieties within the membrane Spanish Ministerio de Ciencia e Innovación—Feder (MAT2011-22544) and by the Junta de Castilla y León (BU001A10-2) application/pdf eng MDPI Sensors, 2012, V. 12, n. 3, p. 2969-2982 http://dx.doi.org/10.3390/s120302969 Attribution 3.0 Unported http://creativecommons.org/licenses/by/3.0/ info:eu-repo/semantics/openAccess sensory materials chemosensor fluorogenic sensor biomolecules sensing biomolecules Chemistry Química An Organic/Inorganic Hybrid Membrane as a Solid “Turn-On” Fluorescent Chemosensor for Coenzyme A (CoA), Cysteine (Cys), and Glutathione (GSH) in Aqueous Media info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion