2026-06-17T18:49:06Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/43922022-05-20T13:22:32Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

Fernández Natal, Isabel Sáez Nieto, J. A. Rodríguez Lázaro, David Valdezate Ramos, S. Parras Padilla, T. Medina, M. J. Rodríguez Pollán, R. H. Blom, J. Tauch, A. Soriano, F. 2017-03-29T09:34:05Z 2017-03-29T09:34:05Z 2016-03 http://hdl.handle.net/10259/4392 During a 12-year period we isolated five Corynebacterium argentoratense strains identified by phenotypic methods, including the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) and 16S rRNA gene sequencing. In addition, antimicrobial susceptibility was determined, and genome sequencing for the detection of antibiotic resistance genes was performed. The organisms were isolated from blood and throat cultures and could be identified by all methods used. All strains were resistant to cotrimoxazole, and resistance to β-lactams was partly present. Two strains were resistant to erythromycin and clindamycin. The draft genome sequences of theses isolates revealed the presence of the erm(X) resistance gene that is embedded in the genetic structure of the transposable element Tn5423. Although rarely reported as a human pathogen, C. argentoratense can be involved in bacteraemia and probably in other infections. Our results also show that horizontal transfer of genes responsible for antibiotic resistance is occurring in this species. Supported in part by the Gerencia Regional de Salud, Junta de Castilla y León, Spain (research project GRS 698/A/2011) application/pdf eng Elsevier New Microbes and New Infections. 2016, V. 10, p. 116–121 http://dx.doi.org/10.1016/j.nmni.2016.01.007 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Antimicrobial resistance clinical infections Corynebacterium argentoratense MALDI-TOF whole genome sequencing Microbiology Microbiología Phenotypic, molecular characterization, antimicrobial susceptibility and draft genome sequence of Corynebacterium argentoratense strains isolated from clinical samples info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion