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oai:riubu.ubu.es:10259/44112022-04-29T12:02:47Zcom_10259_4862com_10259_5086com_10259_2604col_10259_4863

00925njm 22002777a 4500 dc Ariza Miguel, Jaime author Johansson, Anders author Fernández Natal, Isabel author Martínez Nistal, Carmen author Orduña, Antonio author Rodríguez Ferri, F. author Hernández Pérez, Marta author Rodríguez Lázaro, David author 2014-05 Tularemia outbreaks occurred in northwestern Spain in 1997–1998 and 2007–2008 and affected >1,000 persons. We assessed isolates involved in these outbreaks by using pulsed-field gel electrophoresis with 2 restriction enzymes and multilocus variable number tandem repeat analysis of 16 genomic loci of Francisella tularensis, the cause of this disease. Isolates were divided into 3 pulsotypes by pulsed-field gel electrophoresis and 8 allelic profiles by multilocus variable number tandem repeat analysis. Isolates obtained from the second tularemia outbreak had the same genotypes as isolates obtained from the first outbreak. Both outbreaks were caused by genotypes of genetic subclade B.Br:FTNF002–00, which is widely distributed in countries in central and western Europe. Thus, reemergence of tularemia in Spain was not caused by the reintroduction of exotic strains, but probably by persistence of local reservoirs of infection. http://hdl.handle.net/10259/4411 Molecular Investigation of Tularemia Outbreaks, Spain, 1997–2008