2026-06-10T09:09:24Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/44362022-04-29T12:02:48Zcom_10259_4313com_10259_5086com_10259_2604col_10259_4314
Repositorio Institucional de la Universidad de Burgos
author
Morro, Ana
author
Abrusci, Concepción
author
Pablos, Jesús Luis
author
Marín, Irma
author
García García, Félix Clemente
author
García Pérez, José Miguel
2017-04-28T09:26:17Z
2019-06-01T02:45:06Z
2017-06
http://hdl.handle.net/10259/4436
Microbial colonisation of synthetic materials is a great concern in many fields, e.g., in implant surgery and medical devices; therefore biocompatible hydrophilic organic materials with inherent antimicrobial properties are of current research interest. In this work, we describe the preparation of antibacterial and biocompatible polymeric film based on N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl acrylate (HEA), using ethyleneglycol dimethacrylate (EGDMA), and synthetic acrylic monomer containing sulfadiazine chemically anchored. The synthesised polyvinylpyrrolidone (PVP)-based films were characterized by different techniques (1H and 13C NMR, ATR-FTIR, SEM, and TGA). In this study, the biophysical responses of bacteria and L929 cells towards the prepared materials as model device surfaces were evaluated. The membrane that contains the anchored sulfadiazine moiety showed excellent antibacterial activity against Escherichia coli as well as good biocompatibility. Based on the experimental results, this material is a good candidate for medical applications as a biomaterial.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
PVP
Sulfadiazine
Antibacterial polymer
Biocompatible
Inherent antibacterial activity and in vitro biocompatibility of hydrophilic polymer film containing chemically anchored sulfadiazine moieties
info:eu-repo/semantics/article
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Morro-EPJ_2017.pdf.txt