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oai:riubu.ubu.es:10259/45432022-12-19T11:19:05Zcom_10259_3924com_10259_5086com_10259_2604com_10259_4354col_10259_3925col_10259_4355

Pertejo Fernández, Pablo Corres, Nazaret Torroba Pérez, Tomás García Valverde, María Enantiopure 3-carboxamide-1,4-benzodiazepin-5-ones were synthesized via the Ugi reaction followed by the Staudinger/aza-Wittig or reduction reactions in only two steps. A complete reversal of diastereoselectivity was achieved depending on the cyclization methodology employed. The different orientation of the C3 substituent in our 3-substituted 1,4-benzodiazepin-5-ones with respect to the most studied 1,4-benzodiazepin-2-ones makes them complementary in the development of new drugs because the primary source of binding selectivity of 1,4-benzodiazepines is the selective recognition of ligand conformations by the receptor. 2017-07-27 2017-07-27 2015-02-06 info:eu-repo/semantics/article 1523-7060 http://hdl.handle.net/10259/4543 10.1021/ol503628r eng Organic Letters. 2015, V. 17, n. 3, p. 612–615 http://dx.doi.org/10.1021/ol503628r info:eu-repo/grantAgreement/EC/FP7/312411 info:eu-repo/semantics/openAccess American Chemical Society