2026-05-30T19:44:43Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/45432022-12-19T11:19:05Zcom_10259_3924com_10259_5086com_10259_2604com_10259_4354col_10259_3925col_10259_4355

00925njm 22002777a 4500 dc Pertejo Fernández, Pablo author Corres, Nazaret author Torroba Pérez, Tomás author García Valverde, María author 2015-02-06 Enantiopure 3-carboxamide-1,4-benzodiazepin-5-ones were synthesized via the Ugi reaction followed by the Staudinger/aza-Wittig or reduction reactions in only two steps. A complete reversal of diastereoselectivity was achieved depending on the cyclization methodology employed. The different orientation of the C3 substituent in our 3-substituted 1,4-benzodiazepin-5-ones with respect to the most studied 1,4-benzodiazepin-2-ones makes them complementary in the development of new drugs because the primary source of binding selectivity of 1,4-benzodiazepines is the selective recognition of ligand conformations by the receptor. 1523-7060 http://hdl.handle.net/10259/4543 10.1021/ol503628r Reversal of diastereoselectivity in the synthesis of Peptidomimetic 3‑Carboxamide-1,4-benzodiazepin-5-ones