2026-06-19T18:36:02Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/47432022-04-29T12:02:46Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925

00925njm 22002777a 4500 dc Knight, Nicola J. . author Hernando Santa Cruz, Elsa author Haynes, Cally J. E. . author Busschaert, Nathalie author Clarke, Harriet J. . author Takimoto, Koji author García Valverde, María author Frey, Jeremy G. . author Quesada Pato, Roberto author Gale, Philip A. . author 2016-02 The transmembrane anion transport activity of 43 synthetic molecules based on the structure of marine alkaloid tambjamine were assessed in model phospholipid (POPC) liposomes. The anionophoric activity of these molecules showed a parabolic dependence with lipophilicity, with an optimum range for transport efficiency. Using a quantitative structure–transport activity (QSAR) approach it was possible to rationalize these results and to quantify the contribution of lipophilicity to the transport activity of these derivatives. While the optimal value of log P and the curvature of the parabolic dependence is a property of the membrane (and so similar for the different series of substituents) we found that for relatively simple substituents in certain locations on the tambjamine core, hydrophobic interactions clearly dominate, but for others, more specific interactions are present that change the position of the membrane hydrophobicity parabolic envelope. 2041-6520 http://hdl.handle.net/10259/4743 10.1039/c5sc03932k QSAR analysis of substituent effects on tambjamine anion transporters