2026-05-30T21:03:20Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/48762021-11-10T09:38:19Zcom_10259_3924com_10259_5086com_10259_2604col_10259_3925
Repositorio Institucional de la Universidad de Burgos
author
Hernando Santa Cruz, Elsa
author
Soto Cerrato, Vanessa
author
Cortés Arroyo, Susana .
author
Pérez Tomás, Ricardo
author
Quesada Pato, Roberto
2018-08-23T08:29:20Z
2018-08-23T08:29:20Z
2014-03
1477-0520
http://hdl.handle.net/10259/4876
10.1039/c3ob42341g
Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have
been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in
model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the
alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of
these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50
values in the low micromolar range as well as modify the intracellular pH, inducing the basification of
acidic organelles.
eng
Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/4876/3/Hernando-OBC_2014.pdf
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https://riubu.ubu.es/bitstream/10259/4876/4/Hernando-OBC_2014.pdf.txt
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