2026-06-28T11:22:39Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/49292022-12-19T12:26:22Zcom_10259_3593com_10259_5086com_10259_2604com_10259_3596col_10259_3594col_10259_3597

00925njm 22002777a 4500 dc García Tojal, Javier author Gil García, Rubén author Fouz Cuesta, Víctor Ivo author Madariaga, Gotzon author Lezama, Luis author Galletero, María S. author Borrás, Joaquín author Nollmann, Friederike I. author García Girón, Carlos author Alcaraz, Raquel author Cavia Saiz, Mónica author Muñiz Rodríguez, Pilar author Palacios, Óscar author Samper, Katia G. author Rojo, Teófilo author 2018-03 Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands. 0162-0134 http://hdl.handle.net/10259/4929 10.1016/j.jinorgbio.2017.12.005 Colon carcinoma Copper Molecular magnetism Thiosemicarbazone Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines