2026-06-10T14:21:53Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/49292022-12-19T12:26:22Zcom_10259_3593com_10259_5086com_10259_2604com_10259_3596col_10259_3594col_10259_3597
Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines
García Tojal, Javier
Gil García, Rubén
Fouz Cuesta, Víctor Ivo
Madariaga, Gotzon
Lezama, Luis
Galletero, María S.
Borrás, Joaquín
Nollmann, Friederike I.
García Girón, Carlos
Alcaraz, Raquel
Cavia Saiz, Mónica
Muñiz Rodríguez, Pilar
Palacios, Óscar
Samper, Katia G.
Rojo, Teófilo
Colon carcinoma
Copper
Molecular magnetism
Thiosemicarbazone
Química inorgánica
Aparato digestivo-Enfermedades
Chemistry, Inorganic
Digestive organs-Diseases
Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the
potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests
on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the
[Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic
and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu
(PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the
absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with
the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome
c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with
those shown by the free HPTSC and HPTSC* ligands.
Obra Social “la
Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and
FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT,
MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León
(BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Junta
de Castilla y León (GRS 1023/A/14), the Basque Government (project
IT-779-13)
2018-09-10T08:48:17Z
2018-03
2020-04
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
0162-0134
http://hdl.handle.net/10259/4929
10.1016/j.jinorgbio.2017.12.005
eng
Journal of Inorganic Biochemistry. 2018, V. 180, p. 69–79
https://doi.org/10.1016/j.jinorgbio.2017.12.005
info:eu-repo/grantAgreement/FundaciónLaCaixa/ OSLC-2012-007
info:eu-repo/grantAgreement/MINECO/CTQ2013-48937-C2-1-P
info:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT
info:eu-repo/grantAgreement/MINECO/MAT2015-66441-P
info:eu-repo/grantAgreement/MINECO/BIO2015-67358-C2-2-P
info:eu-repo/grantAgreement/JCyL/BU237U13
info:eu-repo/grantAgreement/JCyL/GRS 1023/A/14
info:eu-repo/grantAgreement/GV/IT-779-13
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
application/pdf
Elsevier