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oai:riubu.ubu.es:10259/49292022-12-19T12:26:22Zcom_10259_3593com_10259_5086com_10259_2604com_10259_3596col_10259_3594col_10259_3597

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines García Tojal, Javier Gil García, Rubén Fouz Cuesta, Víctor Ivo Madariaga, Gotzon Lezama, Luis Galletero, María S. Borrás, Joaquín Nollmann, Friederike I. García Girón, Carlos Alcaraz, Raquel Cavia Saiz, Mónica Muñiz Rodríguez, Pilar Palacios, Óscar Samper, Katia G. Rojo, Teófilo Colon carcinoma Copper Molecular magnetism Thiosemicarbazone Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands. 2018-03 info:eu-repo/semantics/article 0162-0134 http://hdl.handle.net/10259/4929 10.1016/j.jinorgbio.2017.12.005 eng Journal of Inorganic Biochemistry. 2018, V. 180, p. 69–79 https://doi.org/10.1016/j.jinorgbio.2017.12.005 info:eu-repo/grantAgreement/FundaciónLaCaixa/ OSLC-2012-007 info:eu-repo/grantAgreement/MINECO/CTQ2013-48937-C2-1-P info:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT info:eu-repo/grantAgreement/MINECO/MAT2015-66441-P info:eu-repo/grantAgreement/MINECO/BIO2015-67358-C2-2-P info:eu-repo/grantAgreement/JCyL/BU237U13 info:eu-repo/grantAgreement/JCyL/GRS 1023/A/14 info:eu-repo/grantAgreement/GV/IT-779-13 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier