2026-08-20T00:45:43Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/49952021-11-10T09:38:26Zcom_10259_4725com_10259_5086com_10259_2604col_10259_4726
Repositorio Institucional de la Universidad de Burgos
author
Bartha, Jose L. .
author
Bugatto, Fernando .
author
Fernández Deudero, Álvaro .
author
Fernández Macías, Rosa .
author
Perdomo Hernández, Germán M.
2018-11-05T09:36:02Z
2018-11-05T09:36:02Z
2016-11
1476-511X
http://hdl.handle.net/10259/4995
10.1186/s12944-016-0373-6
Background: Abnormal fatty acid oxidation (FAO) is associated with maternal and fetal complications during
pregnancy. The contribution of maternal and fetal tissues to FAO capacity during late pregnancy is important to
understand the pathophysiology of pregnancy-associated complications. The aim of this study was to determine
the expression levels of mitochondrial FAO enzymes in maternal and fetal tissues during late normal pregnancy.
Methods: We have measured by Real-time PCR the levels of long- and medium -chain acyl-CoA dehydrogenase
(LCHAD and MCAD), two acyl-CoA dehydrogenases that catalyze the initial step in the mitochondrial FAO spiral.
Results: LCHAD and MCAD were expressed in maternal skeletal muscle, subcutaneous adipose tissue, placenta, and
maternal and fetal blood cells. LCHAD gene expression was four- to 16-fold higher than MCAD gene expression in
placenta, adipose tissue and skeletal muscle. In contrast, MCAD gene expression was ~5-fold higher in fetal blood
than maternal blood (p = 0.02), whereas LCHAD gene expression was similar between fetal blood and maternal
blood (p =0.91).
Conclusions: LCHAD and MCAD are differentially expressed in maternal and fetal tissues during normal late
pregnancy, which may represent a metabolic adaptation in response to physiological maternal dyslipidemia during
late pregnancy.
eng
Attribution 4.0 International
Fatty acid metabolism
Long-chain acyl CoA dehydrogenase
Medium-chain acyl CoA dehydrogenase
Placenta
Tissue specific expression of human fatty acid oxidation enzyme genes in late pregnancy
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/4995/1/Bartha-lhd_%202016.pdf
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