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oai:riubu.ubu.es:10259/50412026-02-06T12:55:16Zcom_10259_4363com_10259_5086com_10259_2604com_10259_4365col_10259_4364col_10259_4366

00925njm 22002777a 4500 dc Martínez Alonso, Marta author Busto Vázquez, Natalia author Aguirre, Larry Danilo author Berlanga, Leticia author Carrión, María C. . author Cuevas Vicario, José Vicente author Rodríguez, Ana M. . author Carbayo Martín, Mª Aránzazu author Manzano, Blanca R. . author Ortí, Enrique . author Jalón Sotés, Félix Ángel author García Ruiz, Begoña author Espino Ordóñez, Gustavo author 2018-11 In this paper, the synthesis, comprehensive characterization and biological and photocatalytic properties of two series of neutral IrIII biscyclometalated complexes of general formula [Ir(C^N)2(N^O)], where the N^O ligands are 2‐(benzimidazolyl)phenolate‐N,O (L1, series a) and 2‐(benzothiazolyl)phenolate‐N,O (L2, series b), and the C^N ligands are 2‐(phenyl)pyridinate or its derivatives, are described,. Complexes of types a and b exhibit dissimilar photophysical and biological properties. In vitro cytotoxicity tests conclusively prove that derivatives of series a are harmless in the dark against SW480 cancer cells (colon adenocarcinoma), but express enhanced cytotoxicity versus the same cells after stimulation with UV or blue light. In contrast, complexes of type b show a very high cytotoxic activity in the dark, but low photosensitizing ability. Thus, the ancillary N^O ligand is the main factor in terms of cytotoxic activity both in the dark and upon irradiation. However, the C^N ligands play a key role regarding cellular uptake. In particular, the complex of formula [Ir(dfppy)2(L1)] (dfppy=2‐(4,6‐difluorophenyl)pyridinate) [3 a] has been identified as both an efficient photosensitizer for 1O2 generation and a potential agent for photodynamic therapy. These capabilities are probably related to a combination of its notable cellular internalization, remarkable photostability, high photoluminescence quantum yield, and long triplet excited‐state lifetime. Both types of complexes exhibit notable catalytic activity in the photooxidation of thioanisole and S‐containing aminoacids with full selectivity. 0947-6539 http://hdl.handle.net/10259/5041 10.1002/chem.201803784 2-arylazoles anticancercomplexes heterolepticneutraliridium(III)complexes phosphorescent complexes photodynamictherapy Strong influence of the ancillary ligand over the photodynamic anticancer properties of neutral biscyclometalated IrIII complexes bearing 2‐benzoazole‐phenolates