2026-04-19T14:07:44Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/51822022-04-26T11:42:13Zcom_10259_2699col_10259_2727

García Ruiz, Begoña 217 500 Leal Villalba, José María 314 500 Lari, Matteo 2e6dd82d-c9d3-4a18-bd1d-287be7960ca0 500 2019-11-13T11:15:44Z 2019-11-13T11:15:44Z 2018 http://hdl.handle.net/10259/5182 10.36443/10259/5182 La Tesis "Interaction of metal complexes with nucleic acids. A thermodynamic and kinetic study, with an eye on photoreactive processes" de Matteo Lari estudia los mecanismos de acción de varias moléculas con ácidos nucleídos. En la primera parte de la Tesis se estudian los efectos Del ion aluminio hacia el ARN, el cual provoca importantes cambios estructurales de ese acido nucleico y favorece su agregación. En la segunda parte se estudia la interacción de complejos metálicos con ADN, como posibles compuestos antitumorales. En particular, estudios de fotoreactividad han revelado que las moléculas sintetizadas incrementan su efecto tras irradiación en la región UV-vis. Además de eso, alguna de esta moléculas tienen una interesante subida de la fluorescencia en presencia de polinucleótidos, y selectividad hacia estructuras no canonícas de ADN, las G-Quadruplex, las cuales incrementan aun más el interés de estas especies como drogas antitumorales. The Thesis "Interaction of metal complexes with nucleic acids. A thermodynamic and kinetic study, with an eye on photoreactive processes" by Matteo Lari regards the study of the mechanisms of action of different kinds of molecules with nucleic acids. The first part of the thesis is centered on the characterization of an aluminium complex and its interaction with RNA, which provokes important structural changes and the formation of aggregates. In the second part, the interaction of metal complexes with DNA is characterized, in the view of their possible use as anticancer drugs. In particular, a focus on their photoreactivity is performed, and it is seen that such complexes enhance their reactivity in the presence of a UV-vis light. In addition, fluorescence enhancement of the complexes is observed by interaction with DNA, and selectivity towards non-canonical DNA structures, the G-Quadruplexes, is found, making these complexes more interesting for anticancer strategy. application/pdf ita http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 Internacional info:eu-repo/semantics/openAccess Aluminio Complejos Metálicos Ácidos Nucleicos Terapia Fotodinámica Cuádruple Hélices Aluminium Metal complexes Nucleic acids Photodynamic therapy G-Quadruplex Química física Chemistry, Physical and theoretical 2301.05 Espectroscopia de Emisión 2302.23 Ácidos Nucleicos 2303.21 Compuestos Organometálicos Interaction of metal complexes with nucleic acid: a thermodynamic and kinetic study, with an eye on photoreactive processes info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/acceptedVersion TEXT Lari.pdf.txt Lari.pdf.txt Extracted text text/plain 462984 https://riubu.ubu.es/bitstream/10259/5182/5/Lari.pdf.txt 1219499bed3c2ee80dbb5e6b516f4507 MD5 5 THUMBNAIL Lari.pdf.jpg Lari.pdf.jpg IM Thumbnail image/jpeg 3806 https://riubu.ubu.es/bitstream/10259/5182/4/Lari.pdf.jpg c76a3df4fa17d624b95d8737c3379192 MD5 4 LICENSE license.txt license.txt text/plain; charset=utf-8 1362 https://riubu.ubu.es/bitstream/10259/5182/3/license.txt 5d013bfa6e473ff0db22cd82a4d71a70 MD5 3 CC-LICENSE license_rdf license_rdf application/rdf+xml; charset=utf-8 805 https://riubu.ubu.es/bitstream/10259/5182/2/license_rdf 4460e5956bc1d1639be9ae6146a50347 MD5 2 ORIGINAL Lari.pdf Lari.pdf application/pdf 12938620 https://riubu.ubu.es/bitstream/10259/5182/1/Lari.pdf 16a04fa07b729c95478174f99cc7763a MD5 1 10259/5182 oai:riubu.ubu.es:10259/5182 2022-04-26 13:42:13.593 Repositorio Institucional de la Universidad de Burgos bubrep@ubu.es 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