2026-06-21T08:13:29Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/52002021-11-10T09:38:27Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597

00925njm 22002777a 4500 dc Rodríguez, María R. author Balsa, Lucía M. author Plá, Julián del author García Tojal, Javier author Pis Diez, Reinaldo author Parajón Costa, Beatriz S. author León, Ignacio E. author González Baró, Ana C. author 2019 From the interaction of the vanadyl ion with a ligand (HL), obtained by the condensation reaction of o-vanillin and 2-thiophenemethylamine, an oxidovanadium(IV) complex (VOL2) was obtained. It was characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance, and UV-vis and EPR, in solution. Its thermal behavior was analyzed by means of TGA and DTA. Theoretical studies based on DFT computational methods aided in the interpretation and assignment of spectroscopic data. Cytotoxicity assays (48 h) against bone cancer cells (MG-63, IC50 = 50.4 ± 8.7), breast cancer cells (MCF-7, IC50 = 42.3 ± 4.7), (MDA-MB-231, IC50 = 29.0 ± 1.7) and a normal fibroblast (L929, IC50 = 71.0 ± 3.5) demonstrated the enhancement of the effectiveness and selectivity of the complex as compared with both the ligand and the free metal ion. Besides, the compound inhibits cell migration, increases ROS levels and facilitates apoptosis. On a whole, these results show the main mechanisms of the deleterious effects of [VOL2] in a triple negative breast cancer cell line (MDA-MB-231), demonstrating that this complex is a promising therapeutic agent for this kind of breast cancer. 1144-0546 http://hdl.handle.net/10259/5200 10.1039/C9NJ02092F 1369-9261 Synthesis, characterization, DFT calculations and anticancer activity of a new oxidovanadium(iv) complex with a ligand derived from o-vanillin and thiophene