2026-05-15T09:01:12Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/52002021-11-10T09:38:27Zcom_10259_3596com_10259_5086com_10259_2604col_10259_3597
Repositorio Institucional de la Universidad de Burgos
author
Rodríguez, María R.
author
Balsa, Lucía M.
author
Plá, Julián del
author
García Tojal, Javier
author
Pis Diez, Reinaldo
author
Parajón Costa, Beatriz S.
author
León, Ignacio E.
author
González Baró, Ana C.
2020-01-08T10:10:24Z
2020-01-08T10:10:24Z
2019
1144-0546
http://hdl.handle.net/10259/5200
10.1039/C9NJ02092F
1369-9261
From the interaction of the vanadyl ion with a ligand (HL), obtained by the condensation reaction of o-vanillin and 2-thiophenemethylamine, an oxidovanadium(IV) complex (VOL2) was obtained. It was characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance, and UV-vis and EPR, in solution. Its thermal behavior was analyzed by means of TGA and DTA. Theoretical studies based on DFT computational methods aided in the interpretation and assignment of spectroscopic data. Cytotoxicity assays (48 h) against bone cancer cells (MG-63, IC50 = 50.4 ± 8.7), breast cancer cells (MCF-7, IC50 = 42.3 ± 4.7), (MDA-MB-231, IC50 = 29.0 ± 1.7) and a normal fibroblast (L929, IC50 = 71.0 ± 3.5) demonstrated the enhancement of the effectiveness and selectivity of the complex as compared with both the ligand and the free metal ion. Besides, the compound inhibits cell migration, increases ROS levels and facilitates apoptosis. On a whole, these results show the main mechanisms of the deleterious effects of [VOL2] in a triple negative breast cancer cell line (MDA-MB-231), demonstrating that this complex is a promising therapeutic agent for this kind of breast cancer.
eng
Synthesis, characterization, DFT calculations and anticancer activity of a new oxidovanadium(iv) complex with a ligand derived from o-vanillin and thiophene
info:eu-repo/semantics/article
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URL
https://riubu.ubu.es/bitstream/10259/5200/1/Rodr%c3%adguez-njc_2019.pdf
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