2026-06-18T06:39:26Zhttps://riubu.ubu.es/oai/request

oai:riubu.ubu.es:10259/52422021-11-02T12:06:21Zcom_10259_4725com_10259_5086com_10259_2604col_10259_4726

Intestinal fructose and glucose metabolism in health and disease Perdomo Hernández, Germán M. Merino, Beatriz Fernández Díaz, Cristina M. . Cózar Castellano, Irene fructose glucose small intestine liver brain gut-brain axis non-alcoholic fatty liver insulin resistance metabolic syndrome type 2 diabetes mellitus The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed. 2020-03-13T09:13:36Z 2020-03-13T09:13:36Z 2020-01 info:eu-repo/semantics/article http://hdl.handle.net/10259/5242 10.3390/nu12010094 2072-6643 eng Nutrients. 2020, V. 12, n. 1, 94 https://doi.org/10.3390/nu12010094 info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-1-R info:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-2-R info:eu-repo/grantAgreement/FundaciónLaCaixa/CAIXA-UBU001 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional MDPI