2026-05-30T04:53:23Zhttps://riubu.ubu.es/oai/requestoai:riubu.ubu.es:10259/53182022-05-30T22:42:07Zcom_10259_3596com_10259_5086com_10259_2604com_10259_4292col_10259_3597col_10259_4293
Repositorio Institucional de la Universidad de Burgos
author
Alcaraz, Raquel
author
Muñiz Rodríguez, Pilar
author
Cavia Saiz, Mónica
author
Palacios, Óscar
author
Samper, Katia G.
author
Gil García, Rubén
author
Jiménez Pérez, Alondra
author
García Tojal, Javier
author
García Girón, Carlos
2020-06-01T15:15:44Z
2020-06-01T15:15:44Z
2020-05
0162-0134
http://hdl.handle.net/10259/5318
10.1016/j.jinorgbio.2020.110993
Colorectal cancer is the third most common type of cancer and has a high incidence in developed countries. At present, specific treatments are being required to allow individualized therapy depending on the molecular alteration on which the drug may act. The aim of this project is to evaluate whether HPTSC and HPTSC* thiosemicarbazones (HPTSC = pyridine-2-carbaldehyde thiosemicarbazone and HPTSC* = pyridine-2-carbaldehyde 4N-methylthiosemicarbazone), and their complexes with different transition metal ions as Cu(II), Fe(III) and Co(III), have antitumor activity in colon cancer cells (HT-29 and SW-480), that have different oncogenic characteristics. Cytotoxicity was evaluated and the involvement of oxidative stress in its mechanism of action was analyzed by quantifying the superoxide dismutase activity, redox state by quantification of the thioredoxin levels and reduced/oxidized glutathione rate and biomolecules damage. The apoptotic effect was evaluated by measurements of the levels of caspase 9 and 3 and the index of histones. All the metal-thiosemicarbazones have antitumor activity mediated by oxidative stress. The HPTSC*-Cu was the compound that showed the best antitumor and apoptotic characteristics for the cell line SW480, that is KRAS gene mutated.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Cell death
Cobalt compounds
Colon carcinoma
Iron compounds
Oxidative stress
Thiosemicarbazone
Thiosemicarbazone-metal complexes exhibiting cytotoxicity in colon cancer cell lines through oxidative stress
info:eu-repo/semantics/article
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